{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Deregulation of long non‐coding RNAs (lncRNAs) is emerging as a key feature in tumorigenesis, with distinct lncRNAs implicated across different malignancies. While one study investigated the lncRNA landscape in tongue squamous cell carcinoma (SCC), identifying several deregulated lncRNAs associated with tumor stage and nodal status (1), another investigation focused on melanoma has highlighted the prognostic importance of autophagy‐related lncRNAs. In the melanoma study, LINC01527 was identified as one of nine autophagy‐related lncRNAs that, when analyzed in a co‐expression network with autophagy‐associated mRNAs, contributed to a prognostic risk model capable of discriminating between high‐ and low‐risk patient groups (3). The inclusion of LINC01527 in this multi‐lncRNA model suggests that its aberrant expression is linked to the regulation of autophagic processes, potentially impacting melanoma progression and patient outcomes by modulating autophagy‐dependent carcinogenic pathways. Although not directly addressed in the tongue SCC study (1) or the second abstract (2), the findings in melanoma emphasize the relevance of LINC01527 as a biomarker that warrants further investigation for its role in autophagy regulation and as a prospective target in precision oncology."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "b", "children": [{"type": "t", "text": "Citations:"}]}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wei Gao, Jimmy Yu-Wai Chan, Thian-Sze Wong "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA deregulation in tongue squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2014/405860"}], "href": "https://doi.org/10.1155/2014/405860"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25045670"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25045670"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ledong Sun, Zhiguang Guan, Shanshan Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Long Non-coding and Messenger RNAs Differentially Expressed Between Primary and Metastatic Melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2019.00292"}], "href": "https://doi.org/10.3389/fgene.2019.00292"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31024618"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31024618"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhehong Li, Junqiang Wei, Honghong Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The new horizon of biomarker in melanoma patients: A study based on autophagy-related long non-coding RNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Medicine (Baltimore) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MD.0000000000028553"}], "href": "https://doi.org/10.1097/MD.0000000000028553"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35029926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35029926"}]}]}]}