{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01534 has emerged as an important long non‐coding RNA in modulating inflammatory processes and matrix integrity in musculoskeletal tissues. In osteoarthritis (OA), LINC01534 is overexpressed in affected cartilage, where it exacerbates IL‐1β–induced chondrocyte dysfunction by promoting extracellular matrix degradation and inflammatory cytokine production. Mechanistically, it acts by sponging miR‑140‑5p, which leads to reduced expression of key matrix proteins (aggrecan and collagen II) and increased levels of matrix metalloproteinases and proinflammatory mediators.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In a related context of debris-induced osteolysis observed after total hip replacement, LINC01534 is similarly upregulated. Here, it functions as a competing endogenous RNA by binding miR‑135b‑5p. This interaction de-represses its downstream target, the CCHC-type zinc finger nucleic acid binding protein (PTPRT), thereby activating the NF‑κB signaling pathway and enhancing the inflammatory response in hip chondrocytes.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although an independent study in multiple myeloma highlighted the broader clinical significance of lincRNAs in disease outcome, it underscores the potential impact of dysregulated lincRNAs like LINC01534 across various pathological settings. Collectively, these findings suggest that LINC01534 contributes to abnormal matrix degradation and inflammation in OA and debris-induced osteolysis, representing a promising therapeutic target in cartilage-related disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wei Wei, Shaoxuan He, Zhihua Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01534 Promotes the Aberrant Metabolic Dysfunction and Inflammation in IL-1β-Simulated Osteoarthritic Chondrocytes by Targeting miR-140-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cartilage (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1947603519888787"}], "href": "https://doi.org/10.1177/1947603519888787"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31735077"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31735077"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mehmet Kemal Samur, Stephane Minvielle, Annamaria Gulla, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long intergenic non-coding RNAs have an independent impact on survival in multiple myeloma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41375-018-0116-y"}], "href": "https://doi.org/10.1038/s41375-018-0116-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29749396"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29749396"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yaling Zhang, Qingsheng Zhu, Qing Fang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01534/miR-135b-5p/PTPRT axis regulates inflammatory response in loosening total hip replacement via modulating NF-κB signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Injury (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.injury.2022.03.022"}], "href": "https://doi.org/10.1016/j.injury.2022.03.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35365349"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35365349"}]}]}]}