{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01535, a long non‐coding RNA, has emerged as a multifunctional regulator in both oncogenesis and osteogenesis. In cervical cancer, LINC01535 functions as a competing endogenous RNA that binds miR‑214, thereby relieving its inhibition on EZH2 and promoting cell proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In esophageal squamous cell carcinoma, its overexpression enhances cell proliferation and impedes apoptosis by modulating the JAK/STAT3 signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Beyond its roles in malignancy, LINC01535 contributes to osteogenesis; during the differentiation of human bone marrow‐derived mesenchymal stem cells, it sponges miR‑3619‑5p to regulate BMP2 expression, thereby facilitating osteoblastic differentiation and cell survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In osteosarcoma, LINC01535 acts by binding miR‑214‑3p and upregulating KCNC4, a mechanism that promotes cell growth, migration, and invasion, and correlates with poor prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Aberrant LINC01535 expression is also implicated in clear cell renal cell carcinoma, where it appears linked to tumor progression"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", and in colorectal cancer, where it sequesters miR‑761 to enhance proliferation, invasion, and chemoresistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Collectively, these studies reveal that LINC01535 modulates key regulatory axes and signaling pathways across diverse tissues by acting as a molecular sponge for various microRNAs, thereby promoting oncogenic processes and influencing osteogenic differentiation. This multifaceted role positions LINC01535 as a potential therapeutic target in both cancer and bone-related disorders.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hongjuan Song, Yuan Liu, Xin Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC01535 promotes cervical cancer progression via targeting the miR-214/EZH2 feedback loop."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.14476"}], "href": "https://doi.org/10.1111/jcmm.14476"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31273925"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31273925"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Y Fang, S Zhang, J Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01535 promotes proliferation and inhibits apoptosis in esophageal squamous cell cancer by activating the JAK/STAT3 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202004_20832"}], "href": "https://doi.org/10.26355/eurrev_202004_20832"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32329845"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32329845"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yiwen Zhao, Yi Chen, Xinyu Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA LINC01535 upregulates BMP2 expression levels to promote osteogenic differentiation via sponging miR‑3619‑5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2020.11635"}], "href": "https://doi.org/10.3892/mmr.2020.11635"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33174047"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33174047"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiaoke Yao, Lingna Wu, Zuchao Gu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01535 Promotes the Development of Osteosarcoma Through Modulating miR-214-3p/KCNC4 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Manag Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/CMAR.S232757"}], "href": "https://doi.org/10.2147/CMAR.S232757"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32753970"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32753970"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zhiming Zhang, Xiaoliang Fu, Yanyao Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01535 Attenuates ccRCC Progression through Regulation of the miR-146b-5p/TRIM2 Axis and Inactivation of the PI3K/Akt Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Oncol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/2153337"}], "href": "https://doi.org/10.1155/2022/2153337"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35342411"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35342411"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Changjie Zhao, Qi Jiang, Lin Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC01535 promotes colorectal cancer development and chemoresistance by sponging miR-761."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Ther Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/etm.2021.10117"}], "href": "https://doi.org/10.3892/etm.2021.10117"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33986850"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33986850"}]}]}]}