{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01541 plays a critical regulatory role in endometrial stromal cells by counteracting processes associated with endometriosis. In response to 17β‐estradiol stimulation, diminished levels of LINC01541 contribute to enhanced epithelial–mesenchymal transition (EMT), cell migration, invasion, and reduced apoptosis. In contrast, overexpression of LINC01541 suppresses EMT and metastasis by promoting apoptosis—marked by increased caspase‐3 expression and decreased Bcl-2 levels—and by downregulating vascular endothelial growth factor A (VEGFA) through repression of the Wnt/β-catenin pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Furthermore, LINC01541 acts as a competing endogenous RNA (ceRNA) by sequestering miR-506-5p, thereby preventing miR-506-5p–mediated inhibition of WNT inhibitory factor 1 (WIF1) and subsequent activation of the Wnt/β-catenin pathway; this mechanism curtails the proliferation, migration, and invasion of endometrial stromal cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In an allied study utilizing single-cell RNA sequencing of first-trimester placental villous and decidual tissues, the intricate network of cell types and intercellular communication within the fetomaternal microenvironment was delineated. Although this work did not focus on LINC01541 directly, it establishes a comprehensive cellular blueprint that underscores the potential significance of noncoding RNAs—such as LINC01541—in maintaining tissue homeostasis and orchestrating cell signaling in reproductive biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hong Mai, Yeping Wei, Yan Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01541 overexpression attenuates the 17β-Estradiol-induced migration and invasion capabilities of endometrial stromal cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Syst Biol Reprod Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/19396368.2018.1549290"}], "href": "https://doi.org/10.1080/19396368.2018.1549290"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30608887"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30608887"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hong Mai, Hong Xu, Huisi Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01541 Functions as a ceRNA to Modulate the Wnt/β-Catenin Pathway by Decoying miR-506-5p in Endometriosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s43032-020-00295-3"}], "href": "https://doi.org/10.1007/s43032-020-00295-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32833189"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32833189"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hemant Suryawanshi, Pavel Morozov, Alexander Straus, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A single-cell survey of the human first-trimester placenta and decidua."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Adv (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/sciadv.aau4788"}], "href": "https://doi.org/10.1126/sciadv.aau4788"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30402542"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30402542"}]}]}]}