{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a study exploring the long non‐coding RNA (lncRNA) landscape in renal cell carcinoma (RCC), next-generation sequencing revealed significant dysregulation of 1,163 lncRNAs between tumor and non-tumor tissues (1). Notably, among the top twenty dysregulated lncRNAs, LINC01543 was found to be substantially down‐regulated. Although no direct functional assays were performed on LINC01543 in this work, its marked reduction in expression in RCC tissues suggests that it could be implicated in the molecular pathways of tumor suppression and may serve as part of a biomarker panel useful for diagnosis and prognosis estimation. This finding, in the context of a broader analysis that additionally identified and functionally characterized lncRNAs such as PVT1, underscores the potential clinical relevance of altered lncRNA expression in RCC (1)."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Julia Bohosova, Marek Kasik, Adela Kubickova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA PVT1 is increased in renal cell carcinoma and affects viability and migration in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.24442"}], "href": "https://doi.org/10.1002/jcla.24442"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35441392"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35441392"}]}]}]}