| Name | long intergenic non-protein coding RNA 1546 |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01546, also known as VAL (Vimentin Associated lncRNA), plays a crucial role in AKT-driven lung adenocarcinoma metastasis. Directly induced by the AKT/STAT3 signaling pathway, VAL functions as a potent pro-metastatic molecule by binding to Vimentin. This binding competitively blocks Trim16-dependent polyubiquitination and degradation of Vimentin, thereby stabilizing Vimentin levels. As a result, VAL promotes tumor invasion, metastasis, and anoikis resistance in an epithelial–mesenchymal transition–independent manner. Moreover, targeting VAL with chemosynthetic siRNAs shows promising therapeutic potential against metastasis driven by AKT overactivation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Han Tian, Rong Lian, Yun Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AKT-induced lncRNA VAL promotes EMT-independent metastasis through diminishing Trim16-dependent Vimentin degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-020-18929-0"}], "href": "https://doi.org/10.1038/s41467-020-18929-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33046716"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33046716"}]}]}]}
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| Synonyms | CXORF28 |
| Proteins | CX028_HUMAN |
| NCBI Gene ID | 100129464 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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LINC01546 has 362 functional associations with biological entities spanning 4 categories (molecular profile, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 12 datasets.
Click the + buttons to view associations for LINC01546 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of LINC01546 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of LINC01546 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at LINC01546 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of LINC01546 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of LINC01546 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of LINC01546 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of LINC01546 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of LINC01546 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of LINC01546 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of LINC01546 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of LINC01546 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at LINC01546 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
