{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNAs (lncRNAs) have emerged as key regulators in many human diseases, including cancer. In one recent study focused on hepatocellular carcinoma (HCC) with underlying cirrhosis, LINC01549 was identified as one of four lncRNAs (along with LINC02086, LINC00880, and AC136475.3) used to develop a risk scoring system that independently predicts overall survival (OS) in affected patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Functional enrichment analyses in that work suggested that the implicated lncRNAs—including LINC01549—are involved in oncogenic pathways such as Wnt signaling and cytokine–cytokine receptor interactions, which are known to influence tumor progression. As accumulating evidence supports the broader role of lncRNAs in cancer biology—for example, in regulating proliferation, migration, survival, and genomic stability in oral squamous cell carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "and as emerging biomarkers in breast cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "—the specific inclusion of LINC01549 in the HCC risk model underscores its potential clinical relevance as a prognostic biomarker. This focus on lncRNAs complements studies in other disease contexts, such as Down syndrome"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "and cardiovascular event risk among African Americans"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", although in those settings the role of LINC01549 itself was not highlighted. Together, these findings suggest that further investigation of LINC01549 may provide novel insights into HCC pathogenesis and support its potential utility in clinical prognostication.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jiaxiang Ye, Haixia Li, Jiazhang Wei, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Behav Brain Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbr.2010.10.023"}], "href": "https://doi.org/10.1016/j.bbr.2010.10.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21047530"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21047530"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Aditi Shendre, Marguerite R Irvin, Howard Wiener, et al. 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