{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01554 is a long noncoding RNA that appears to act as a tumor suppressor in certain cancers. In hepatocellular carcinoma (HCC), LINC01554 is significantly downregulated in tumor tissues, and its lower expression is associated with more aggressive clinical features such as advanced pathological stage and increased invasiveness. Functional studies demonstrate that overexpression of LINC01554 inhibits HCC cell proliferation, migration, and invasion by promoting cell cycle arrest at the G0/G1 phase. Mechanistically, LINC01554 interferes with epithelial‑to‑mesenchymal transition (EMT) processes by modulating the expression of key markers – increasing levels of epithelial proteins (such as ZO‑1 and E‑cadherin) and decreasing mesenchymal markers (including N‑cadherin and vimentin). Moreover, LINC01554 suppresses oncogenic signaling pathways (notably PI3K‑Akt and Wnt/β‑catenin), thereby dampening signals that normally promote tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its role in inhibiting signaling pathways, LINC01554 also exerts regulatory effects at the post‑transcriptional level. It functions as a competitive endogenous RNA by binding to microRNA‑3681‑3p, which in turn modulates the expression of nerve growth factor receptor (NGFR), thereby contributing to the suppression of HCC progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Similar tumor‑suppressive features of LINC01554 have also been observed in epithelial ovarian cancer, where its markedly reduced expression in tumor samples compared with adjacent non‑tumor tissue suggests that it may serve as a diagnostic and prognostic biomarker, as well as a potential therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings indicate that LINC01554 modulates cancer cell behavior by inhibiting pathways critical for cell proliferation, migration, and EMT, highlighting its potential as both a biomarker and a therapeutic target in HCC and possibly other cancers.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ling Li, Kang Huang, Zhongshan Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bioinformatics analysis of LINC01554 and its co‑expressed genes in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2020.7779"}], "href": "https://doi.org/10.3892/or.2020.7779"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33000250"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33000250"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Q-Y Hao, L-H Gao, W-Y Niu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long-chain non-coding RNA LINC01554 promotes NGFR expression and inhibits cell proliferation, migration, and invasion in hepatocellular carcinoma by binding to microRNA-3681-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202012_24164"}], "href": "https://doi.org/10.26355/eurrev_202012_24164"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33378013"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33378013"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ting Luo, Yan Jiang, Jing Yang "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA LINC01554 as a Novel Biomarker for Diagnosis and Prognosis Prediction of Epithelial Ovarian Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Markers (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/1244612"}], "href": "https://doi.org/10.1155/2021/1244612"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34422133"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34422133"}]}]}]}