{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have identified LINC01555 as an oncogenic long non‐coding RNA that is upregulated in various gastrointestinal cancers and is associated with tumor progression. In gastric cancer, LINC01555 is significantly overexpressed, and its silencing leads to reduced cell proliferation, colony formation, migration, and invasion, with evidence indicating that these effects are mediated, at least in part, through modulation of the Notch signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In colorectal adenocarcinoma, LINC01555 has been incorporated into a four‐lncRNA prognostic signature, with its expression correlating with overall survival and implicating involvement in pathways such as cAMP signaling and mucin-type O‑Glycan biosynthesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Furthermore, in colorectal cancer, elevated levels of LINC01555 are associated with advanced tumor stage and poor patient outcomes, while its knockdown markedly inhibits cancer cell migration and invasion—effects that are linked to the upregulation of the neuropeptide neuromedin U."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " \n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Complementary findings from location-specific analyses in colon cancer further support the clinical relevance of LINC01555. Its differential expression between right- and left-sided tumors has contributed to the development of an lncRNA-based prognostic signature, reinforcing its potential utility as a biomarker for patient stratification."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies suggest that LINC01555 plays a pivotal role in promoting tumor proliferation, invasion, and metastasis in gastrointestinal malignancies, highlighting its promise both as a therapeutic target and as a prognostic biomarker.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaolian Zhao, Zixuan Zhao "}, {"type": "b", "children": [{"type": "t", "text": "Linc01555 promotes proliferation, migration and invasion of gastric carcinoma cells by interacting with Notch signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J BUON (2020)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32521899"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32521899"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jiang-Hui Zeng, Liang Liang, Rong-Quan He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive investigation of a novel differentially expressed lncRNA expression profile signature to assess the survival of patients with colorectal adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.15161"}], "href": "https://doi.org/10.18632/oncotarget.15161"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28187432"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28187432"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaodong Wang, Xiang Chen, Haihua Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Long Noncoding RNA, LINC01555, Promotes Invasion and Metastasis of Colorectal Cancer by Activating the Neuropeptide, Neuromedin U."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/MSM.916508"}], "href": "https://doi.org/10.12659/MSM.916508"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31144675"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31144675"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ke-Zhi Li, Yi-Xin Yin, Yan-Ping Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction of a long noncoding RNA-based competing endogenous RNA network and prognostic signatures of left- and right-side colon cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-021-01901-3"}], "href": "https://doi.org/10.1186/s12935-021-01901-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33858429"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33858429"}]}]}]}