{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01559 is a long intergenic noncoding RNA that has been found to be upregulated in several human cancers, including pancreatic, gastric, hepatocellular, colorectal, lung, and renal cell carcinomas, and is also implicated as a genetic modifier in Huntington disease. Functionally, LINC01559 generally acts as an oncogene by promoting cell proliferation, migration, invasion, tumor growth, and chemoresistance.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In pancreatic cancer, LINC01559 is highly expressed and enhances tumor progression by serving as a competing endogenous RNA (ceRNA). It sponges microRNAs such as miR‑607 and miR‑1343‑3p to derepress key effectors – for instance, increasing Yes‑associated protein (YAP) activity through both sequestration of miR‑607 and direct interaction that inhibits YAP phosphorylation, as well as upregulating RAF1 to activate the ERK pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In gastric cancer, elevated LINC01559 not only promotes proliferation and migration but also regulates epithelial–mesenchymal transition. Its transcription is activated by ZEB1, and it in turn recruits IGF2BP2 to stabilize ZEB1 mRNA, establishing a positive feedback loop. Moreover, LINC01559 can be transferred to cancer cells via mesenchymal stem cell–derived exosomes where it sponges miR‑1343‑3p to upregulate PGK1 and cooperates with EZH2 to repress PTEN expression, thereby activating the PI3K/AKT signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In hepatocellular carcinoma, studies indicate that LINC01559 contributes to aggressive cell behavior and chemoresistance by sponging miR‑6783‑3p and miR‑511, which leads to the upregulation of targets like SLC38A1 that drive malignant phenotypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Similarly, in colorectal cancer, LINC01559 promotes tumor progression by acting as a ceRNA against miR‑1343‑3p to modulate PARP1 and further influence the PTEN/AKT pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In lung adenocarcinoma, increased levels of LINC01559 have been correlated with lymph node metastasis and poor prognosis; mechanistic studies suggest that it enhances proliferation and migration by promoting autophagy via miR‑1343‑3p sponging."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, LINC01559 is emerging as a component of prognostic gene signatures in hepatocellular and renal cell carcinomas, where its expression can serve as a diagnostic biomarker and may help in stratifying patient risk."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond cancer, genetic variation within the LINC01559 locus has been associated with modifying the age of onset in Huntington disease, highlighting a potential role in non‐oncogenic processes as well."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, LINC01559 exerts its oncogenic functions primarily by acting as a sponge for specific microRNAs, thereby modulating key signaling pathways such as YAP/RAF1–ERK, PI3K/AKT, and PTEN/AKT. Its involvement in multiple cancer-related processes and in chemoresistance underscores its potential as both a prognostic biomarker and a therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Changjie Lou, Juan Zhao, Yuanlong Gu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01559 accelerates pancreatic cancer cell proliferation and migration through YAP-mediated pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29288"}], "href": "https://doi.org/10.1002/jcp.29288"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31608998"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31608998"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiao Chen, Jie Wang, Fei Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC01559 promotes pancreatic cancer progression by acting as a competing endogenous RNA of miR-1343-3p to upregulate RAF1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.103487"}], "href": "https://doi.org/10.18632/aging.103487"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32678071"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32678071"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Huojian Shen, Hongyi Zhu, Yuanwen Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZEB1-induced LINC01559 expedites cell proliferation, migration and EMT process in gastric cancer through recruiting IGF2BP2 to stabilize ZEB1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-03571-5"}], "href": "https://doi.org/10.1038/s41419-021-03571-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33824282"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33824282"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Liyan Wang, Xiaotong Bo, Xiaoyuan Yi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosome-transferred LINC01559 promotes the progression of gastric cancer via PI3K/AKT signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-02810-5"}], "href": "https://doi.org/10.1038/s41419-020-02810-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32895368"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32895368"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Shunbin Dong, Ying Fu, Kaibo Yang, et al. 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