{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies indicate that LINC01561, a novel oncogenic long non‐coding RNA, plays a critical role in tumor progression across multiple cancer types. In breast cancer cells, elevated LINC01561 expression is associated with reduced miR‐145‑5p levels and increased MMP11 expression; silencing LINC01561 results in upregulation of miR‑145‑5p, subsequent downregulation of MMP11, inhibition of cell proliferation, and enhanced apoptosis—findings that support a competing endogenous RNA (ceRNA) mechanism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In non‐small‐cell lung carcinoma, LINC01561 is markedly overexpressed under the transcriptional control of SOX2. It exerts its tumor‐promoting effects by directly binding to miR‑760, thereby relieving repression of its target SHCBP1, which in turn facilitates cell proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Furthermore, integrative expression analyses in lung squamous cell carcinoma have implicated LINC01561 within broader non‐coding RNA regulatory networks governing key oncogenic hub genes, thereby underscoring its potential contribution to malignant progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Collectively, these findings highlight the critical regulatory function of LINC01561 in modulating microRNA activity and downstream oncogene expression, suggesting that it may serve as a promising diagnostic biomarker and therapeutic target in cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rui Jiang, Chunming Zhao, Binbin Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mixomics analysis of breast cancer: Long non-coding RNA linc01561 acts as ceRNA involved in the progression of breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2018.06.003"}], "href": "https://doi.org/10.1016/j.biocel.2018.06.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29890225"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29890225"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wei Gao, Chao-Qun Qi, Mao-Guo Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SOX2-induced upregulation of lncRNA LINC01561 promotes non-small-cell lung carcinoma progression by sponging miR-760 to modulate SHCBP1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29564"}], "href": "https://doi.org/10.1002/jcp.29564"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32003010"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32003010"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yangfeng Shi, Yeping Li, Chao Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of key genes and evaluation of clinical outcomes in lung squamous cell carcinoma using integrated bioinformatics analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Lett (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ol.2019.10933"}], "href": "https://doi.org/10.3892/ol.2019.10933"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31788059"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31788059"}]}]}]}