{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent research has identified LINC01564 as a multifunctional long non‐coding RNA that significantly contributes to oncogenic processes. In hepatocellular carcinoma, LINC01564 is induced by ATF4 during glucose deprivation and acts as a competing endogenous RNA that sequesters miR‑107/103a‑3p, leading to upregulation of PHGDH—the rate‐limiting enzyme of the serine synthesis pathway—thereby promoting metabolic adaptation and tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In glioma, elevated levels of LINC01564 have been shown to enhance temozolomide resistance. Mechanistic studies reveal that LINC01564, together with SRSF1, facilitates the upregulation of NFE2L2 through modulation of MAPK8 activity, which in turn inhibits ferroptosis, favoring cell survival and chemoresistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, in testicular cancer, high expression of LINC01564 is associated with poor overall survival, suggesting its potential as a prognostic biomarker and highlighting its relevance in the tumor microenvironment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these studies underscore LINC01564 as an important regulator of metabolic adaptation and drug resistance in cancer cells, revealing its promise as a potential therapeutic target across diverse oncologic contexts.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Guang Zhang, Yang Yang, Hao Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Energy stress-induced linc01564 activates the serine synthesis pathway and facilitates hepatocellular carcinogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-021-01749-x"}], "href": "https://doi.org/10.1038/s41388-021-01749-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33742121"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33742121"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chixing Luo, Chuansheng Nie, Yibin Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01564 Promotes the TMZ Resistance of Glioma Cells by Upregulating NFE2L2 Expression to Inhibit Ferroptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Neurobiol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12035-022-02736-3"}], "href": "https://doi.org/10.1007/s12035-022-02736-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35420382"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35420382"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhi-Bin Ke, Yu-Peng Wu, Peng Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of novel genes in testicular cancer microenvironment based on ESTIMATE algorithm-derived immune scores."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29898"}], "href": "https://doi.org/10.1002/jcp.29898"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32617980"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32617980"}]}]}]}