{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have underscored the oncogenic role of certain long noncoding RNAs (lncRNAs) in colorectal cancer (CRC). In one study, a lncRNA designated SLCO4A1‐AS1—which in some databases is also known as LINC01567—was found to be significantly upregulated in CRC tissues and associated with poor prognosis. Functional assays revealed that its overexpression promoted cell proliferation, migration, invasion, and epithelial–mesenchymal transition (EMT), while concurrently inhibiting apoptosis. Mechanistically, this lncRNA enhances the stability of β‐catenin through interference with its interaction with GSKβ, thereby activating the Wnt/β‐catenin signaling pathway and driving tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In parallel, another study investigating colon cancer stem cells (CSCs) identified a distinct lncRNA—LOCCS—that was markedly upregulated in a highly tumorigenic subpopulation of colon cancer cells. Knockdown of LOCCS led to reduced cell proliferation, migration, invasion, and impaired xenograft formation. These effects were mediated, at least in part, by a regulatory axis involving reciprocal repression with microRNA-93 (miR-93) and the stem cell marker Musashi-1, suggesting that LOCCS helps maintain CSC-like properties in colon cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n A third investigation focused on lncRNA PVT1, which was shown to be overexpressed in colon cancer tissues relative to adjacent normal tissues. PVT1 appears to facilitate tumor cell proliferation, migration, and invasion by acting as a competing endogenous RNA to sponge miR-26b. The consequent downregulation of miR-26b removes its inhibitory effect on tumorigenic processes, thereby further contributing to cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings indicate that LINC01567 (when considered as synonymous with or functionally related to SLCO4A1‐AS1), along with other oncogenic lncRNAs like LOCCS and PVT1, plays a multifaceted role in CRC tumorigenesis. By modulating key signaling pathways—such as Wnt/β‐catenin—and interacting with critical microRNAs, these lncRNAs drive various malignant phenotypes including enhanced proliferation, migration, invasion, and maintenance of cancer stem cell properties. This highlights their potential utility as diagnostic, prognostic, and therapeutic targets in colorectal cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jiangtao Yu, Zhiyang Han, Ziquan Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SLCO4A1-AS1 facilitates growth and metastasis of colorectal cancer through β-catenin-dependent Wnt pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-018-0896-y"}], "href": "https://doi.org/10.1186/s13046-018-0896-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30201010"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30201010"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaofeng Yu, Lin Mi, Jie Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long intergenic non-protein-coding RNA 1567 (LINC01567) acts as a \"sponge\" against microRNA-93 in regulating the proliferation and tumorigenesis of human colon cancer stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-017-3731-5"}], "href": "https://doi.org/10.1186/s12885-017-3731-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29110645"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29110645"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Rui Zhang, Jibin Li, Xiaofei Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA Plasmacytoma Variant Translocation 1 (PVT1) Promotes Colon Cancer Progression via Endogenous Sponging miR-26b."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/MSM.910955"}], "href": "https://doi.org/10.12659/MSM.910955"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30504754"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30504754"}]}]}]}