{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Although the provided abstract"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "does not explicitly mention LINC01570, it highlights a genomic locus marked by the SNP rs6500843 that is associated with differential survival in breast cancer patients receiving adjuvant chemotherapy. The study found that patients with the rs6500843-GG genotype experienced a higher hazard ratio, and trans‐eQTL analyses linked this locus to the expression of several cell cycle–related genes (notably AURKA). The authors propose that this regulatory effect may be mediated via a RBFOX1–FOXM1 axis. Given that long intergenic noncoding RNAs (lincRNAs) like LINC01570 are known to participate in gene regulation and cellular pathway modulation, it is plausible to consider that LINC01570—if located within or near this associated region—could contribute to fine‐tuning this regulatory network. In this context, LINC01570 may play a role in modulating cell cycle control mechanisms that influence the response to chemotherapy in breast cancer, although its precise function remains to be experimentally defined.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rainer Fagerholm, Marjanka K Schmidt, Sofia Khan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The SNP rs6500843 in 16p13.3 is associated with survival specifically among chemotherapy-treated breast cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.3506"}], "href": "https://doi.org/10.18632/oncotarget.3506"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25823661"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25823661"}]}]}]}