{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01572, a long non‐coding RNA, has emerged as a multifunctional regulator in diverse pathological contexts. A genome‐wide association study implicated a variant in LINC01572 in the susceptibility to neck or shoulder pain, suggesting its potential involvement in pain perception (a genetic locus identified in study."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the setting of polycystic ovary syndrome, an isoform designated LINC‐01572:28 is up‐regulated in luteinized granulosa cells; its increased expression correlates with higher basal testosterone levels and is associated with reduced cell proliferation and a G1/S cell cycle arrest. Mechanistically, LINC‐01572:28 appears to stabilize the p27 protein by interfering with SKP2‐mediated degradation (as demonstrated in."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, studies in gastric cancer have shown that overexpression of LINC01572 promotes chemotherapy resistance by enhancing autophagy. Functioning as a competitive endogenous RNA for miR‐497‐5p, LINC01572 relieves the suppression of ATG14, thereby facilitating autophagy induction in drug‐resistant cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Complementary computational analyses have predicted potential interactions between LINC01572 and specific proteins, offering further insights into its broad regulatory roles."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings underscore the diverse functional roles of LINC01572 in modulating pain sensitivity, cell cycle progression in ovarian pathology, and chemotherapy response in cancer, highlighting its potential as a biomarker and therapeutic target in multiple disease settings."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Weihua Meng, Brian W Chan, Cameron Harris, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genome-wide association study finds genetic variants associated with neck or shoulder pain in UK Biobank."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddaa058"}], "href": "https://doi.org/10.1093/hmg/ddaa058"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32246137"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32246137"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jun Zhao, Jieying Xu, Wangshen Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC-01572:28 inhibits granulosa cell growth via a decrease in p27 (Kip1) degradation in patients with polycystic ovary syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EBioMedicine (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ebiom.2018.09.043"}], "href": "https://doi.org/10.1016/j.ebiom.2018.09.043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30293818"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30293818"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhe Song, Nan Jia, Wei Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01572 Regulates Cisplatin Resistance in Gastric Cancer Cells by Mediating miR-497-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S267915"}], "href": "https://doi.org/10.2147/OTT.S267915"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33149605"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33149605"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Liqian Zhou, Zhao Wang, Xiongfei Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LPI-deepGBDT: a multiple-layer deep framework based on gradient boosting decision trees for lncRNA-protein interaction identification."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Bioinformatics (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12859-021-04399-8"}], "href": "https://doi.org/10.1186/s12859-021-04399-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34607567"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34607567"}]}]}]}