{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01574 has been identified as a prognostic long non‐coding RNA in glioblastoma multiforme (GBM). In a recent study (1), integrated analyses of multiple datasets uncovered a competing endogenous RNA network in which LINC01574, together with other lncRNAs (including H19, LINC01614, RNF144A‐AS1, and OSMR‐AS1), was significantly associated with overall patient survival. In this context, LINC01574 is part of a molecular cascade that involves H19 and hsa‐miR‑338‑3P, leading to the regulation of NRP1—a gene that was found to be both highly expressed in GBM patients and an independent prognostic factor. Although other investigations have detailed the roles of lncRNAs in cell type–specific transcriptional regulation and disease processes such as diabetes and autoimmune disorders (2,3,4), the current findings highlight that, in GBM specifically, LINC01574 and its associated network components hold promise as prognostic biomarkers and potential therapeutic targets."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yong Liu, Yuelin Liu, Yong Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "H19- and hsa-miR-338-3p-mediated NRP1 expression is an independent predictor of poor prognosis in glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0260103"}], "href": "https://doi.org/10.1371/journal.pone.0260103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34843522"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34843522"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ildem Akerman, Zhidong Tu, Anthony Beucher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Metab (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cmet.2016.11.016"}], "href": "https://doi.org/10.1016/j.cmet.2016.11.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28041957"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28041957"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaoyun He, Chunlin Ou, Yanhua Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNAs: key players and novel insights into diabetes mellitus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.19921"}], "href": "https://doi.org/10.18632/oncotarget.19921"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29050364"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29050364"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Aashiq H Mirza, Simranjeet Kaur, Flemming Pociot "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNAs as novel players in β cell function and type 1 diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genomics (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s40246-017-0113-7"}], "href": "https://doi.org/10.1186/s40246-017-0113-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28738846"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28738846"}]}]}]}