{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNA LINC01578 has emerged as an oncogenic regulator in different cancer contexts. In radiation‐resistant non‐small‐cell lung cancer cells, elevated LINC01578 levels promote cell viability and other aggressive cellular functions by downregulating miR‑216b‑5p, thereby allowing upregulation of TBL1XR1, which contributes to the radiation‐resistant phenotype."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In colon cancer, increased LINC01578 expression is associated with metastasis and poor clinical outcomes. Here, transcription factors NF‑κB and YY1 activate LINC01578 expression, and the lncRNA in turn localizes to chromatin where it binds the promoter of NFKBIB. By recruiting EZH2 to repress NFKBIB, LINC01578 sustains NF‑κB signaling; NF‑κB activity further upregulates YY1, establishing a positive feedback loop that reinforces LINC01578 expression and enhances metastatic potential."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Peirong Wang, Linchun Ke, Chuanshu Cai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01578 affects the radiation resistance of lung cancer cells through regulating microRNA-216b-5p/TBL1XR1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2051881"}], "href": "https://doi.org/10.1080/21655979.2022.2051881"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35475502"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35475502"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jia Liu, Yang Zhan, Jiefu Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC01578 drives colon cancer metastasis through a positive feedback loop with the NF-κB/YY1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.12819"}], "href": "https://doi.org/10.1002/1878-0261.12819"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33040438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33040438"}]}]}]}