{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNAs (lncRNAs) have emerged as important regulators in a variety of biological settings. One study systematically analyzed RNA‐sequencing data from the human cumulus–oocyte complex, identifying a set of lncRNAs that are abundant in metaphase II oocytes and cumulus cells and that are implicated in processes such as chromatin remodeling, cell pluripotency, apoptosis, and extracellular matrix organization."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, another study specifically investigated the role of the long intergenic nonprotein coding RNA LINC01579 in glioblastoma. In glioblastoma cells, LINC01579 was found to be upregulated, and its knockdown resulted in inhibited cell proliferation and increased apoptosis. Mechanistic experiments demonstrated that LINC01579 functions as a molecular sponge for miR-139-5p, thereby mitigating the miRNA’s suppression of eukaryotic translation initiation factor 4 gamma 2 (EIF4G2). Rescue assays further revealed that overexpression of EIF4G2 or inhibition of miR-139-5p can partially reverse the effects of LINC01579 knockdown, highlighting its central role in promoting tumor growth and survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings underscore the context-specific functions of lncRNAs—while several lncRNAs may contribute to the regulation and quality of the human cumulus–oocyte complex in reproductive biology, LINC01579 in particular has been identified as an oncogenic factor in glioblastoma by modulating cell proliferation and apoptosis through a competitive endogenous RNA mechanism.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Julien Bouckenheimer, Patricia Fauque, Charles-Henri Lecellier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential long non-coding RNA expression profiles in human oocytes and cumulus cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-20727-0"}], "href": "https://doi.org/10.1038/s41598-018-20727-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29396444"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29396444"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yang Chai, Mingxiang Xie "}, {"type": "b", "children": [{"type": "t", "text": "LINC01579 promotes cell proliferation by acting as a ceRNA of miR-139-5p to upregulate EIF4G2 expression in glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.28933"}], "href": "https://doi.org/10.1002/jcp.28933"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31187495"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31187495"}]}]}]}