{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies underscore the critical role of transcriptional regulation in cancer through mechanisms that affect both coding and non‐coding genes. In one study, pharmacological inhibition of bromodomain and extra‐terminal (BET) proteins—whose displacement from chromatin alters RNA Pol II pausing at promoter regions—was shown to perturb the transcriptional landscape in acute myeloid leukemia, highlighting the importance of proper transcriptional control for tumor sensitivity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Meanwhile, an investigation in breast cancer has identified the long non‐coding RNA LINC01585 as a key regulatory molecule that is aberrantly downregulated in tumor tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Mechanistically, LINC01585 is localized in the nucleus where it binds to the NONO protein, thereby restricting NONO’s interaction with CRTC. When LINC01585 expression is reduced, NONO is liberated to form a complex with CRTC, which in turn enhances cAMP/CREB‐mediated target gene transcription, promoting cancer cell proliferation and tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Collectively, these findings suggest that dysregulation of lncRNAs such as LINC01585 can disrupt normal transcriptional repression mechanisms, contributing to oncogenic transcriptional cascades and representing a promising avenue for anticancer therapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "P Khoueiry, A Ward Gahlawat, M Petretich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Epigenetics Chromatin (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13072-019-0286-5"}], "href": "https://doi.org/10.1186/s13072-019-0286-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31266503"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31266503"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Rui Ma, Xiaoming Zhai, Xun Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01585 functions as a regulator of gene expression by the CAMP/CREB signaling pathway in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2018.10.063"}], "href": "https://doi.org/10.1016/j.gene.2018.10.063"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30366079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30366079"}]}]}]}