{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe study demonstrates that LINC01592 plays a pivotal role in regulating the epithelial‐to‐mesenchymal transition (EMT) in human retinal pigment epithelial (hRPE) cells upon stimulation by transforming growth factor‐β1 (TGF‑β1). Exposure to TGF‑β1 (10 ng/mL for 48 hours) upregulated LINC01592, which was associated with decreased expression of the epithelial marker E‑cadherin, along with alterations in mesenchymal markers such as increased levels of α‑smooth muscle actin (α‑SMA) and Snail. These changes are indicative of EMT activation, a critical process in the pathogenesis of proliferative vitreoretinopathy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFunctional assays further revealed that silencing LINC01592 notably reduced the TGF‑β1‑induced EMT process, whereas its overexpression enhanced the viability, proliferation, and migration of hRPE cells. This regulatory influence suggests that LINC01592 is not only a marker of EMT but also a mediator of the cellular changes underlying this transition. Consequently, targeting LINC01592 may offer a novel therapeutic approach for treating proliferative vitreoretinopathy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ying Su, Ziyan Tang, Feng Wang "}, {"type": "b", "children": [{"type": "t", "text": "Role of LINC01592 in TGF-β1-induced epithelial-mesenchymal transition of retinal pigment epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.203023"}], "href": "https://doi.org/10.18632/aging.203023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34032608"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34032608"}]}]}]}