{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations into the molecular basis of thyroid dysgenesis have identified the long intergenic non‐coding RNA LINC01602 (originally designated T1560) as an important transcriptional target of thyroid-specific factors TTF-2 and TTF-1. LINC01602 exhibits a highly thyroid-specific expression pattern, indicating that it plays a pivotal role in thyroid development and function. Its upregulation by these transcription factors suggests that LINC01602 could contribute to proper thyroid organogenesis, while its dysregulation may be involved in congenital hypothyroidism associated with thyroid dysgenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Dis primis duis mauris potenti non at sociosqu ultricies massa. Tincidunt vel sagittis quam convallis varius phasellus tincidunt. Libero ultrices libero fermentum lectus ex nunc felis. Turpis felis lectus feugiat sapien sagittis. Interdum diam tempor quisque lacinia lobortis libero. Posuere ex nam mi libero gravida aliquet donec. Ligula ultrices quisque rutrum odio leo pulvinar; dictumst hendrerit sollicitudin. Duis nisl gravida justo hendrerit eros sodales morbi."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Akira Hishinuma, Narumi Ohmika, Takashi Namatame, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TTF-2 stimulates expression of 17 genes, including one novel thyroid-specific gene which might be involved in thyroid development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Endocrinol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mce.2004.04.003"}], "href": "https://doi.org/10.1016/j.mce.2004.04.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15223130"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15223130"}]}]}]}