{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nStudies have revealed that LINC01605, also known as lincDUSP, is a long non‐coding RNA with oncogenic properties in several cancer types. In colon cancer models, for example, LINC01605 has been shown to promote cell proliferation and clonogenic potential while modulating the DNA damage response and cell cycle pathways. Its chromatin occupancy is enriched on genes involved in replication‐associated DNA repair, and silencing of LINC01605 results in S-phase accumulation and increased DNA damage markers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nIn triple-negative breast cancer, LINC01605 expression is significantly increased and is associated with lower patient survival. Functional experiments demonstrate that knockdown of LINC01605 markedly reduces cellular proliferation, migration, invasion, and aerobic glycolysis—effects partially mediated by the downregulation of lactate dehydrogenase A. In addition, mutant p53 directly regulates LINC01605 through enhancer binding, linking this lncRNA to mutant p53-driven pro-migratory pathways in breast and ovarian cancer models."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n \nAdditional investigations in laryngeal squamous cell carcinoma, colorectal cancer, and cervical cancer further support a role for LINC01605 in tumor progression. In colorectal cancer, the LINC01605/miR‑3960/SOX11 regulatory axis has been implicated in modulating malignant cell behaviors, while preliminary findings in LSCC and cervical cancer point to its involvement in promoting cellular proliferation and invasion."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Megan E Forrest, Alina Saiakhova, Lydia Beard, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "LINC01605 promotes aerobic glycolysis through lactate dehydrogenase A in triple-negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.15370"}], "href": "https://doi.org/10.1111/cas.15370"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35411612"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35411612"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Michela Coan, Martina Toso, Laura Cesaratto, et al. "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "LINC01605"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Is a Novel Target of Mutant p53 in Breast and Ovarian Cancer Cell Lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms241813736"}], "href": "https://doi.org/10.3390/ijms241813736"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37762037"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37762037"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "X-Y Wang, L Wang, P-C Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01605 promotes the proliferation of laryngeal squamous cell carcinoma through targeting miR-493-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201912_19677"}], "href": "https://doi.org/10.26355/eurrev_201912_19677"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31841192"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31841192"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "S-S Hu, L Fu, S-Y Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01605 regulates proliferation, migration and invasion of colorectal cancer cells via targeting miR-3960/SOX11."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202102_24837"}], "href": "https://doi.org/10.26355/eurrev_202102_24837"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33629302"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33629302"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiaoyu Kong, Yuanpeng Xiong, Liping Li "}, {"type": "b", "children": [{"type": "t", "text": "LINC01605 promotes malignant phenotypes of cervical cancer via miR-149-3p/WNT7B axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2024.148518"}], "href": "https://doi.org/10.1016/j.gene.2024.148518"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38734188"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38734188"}]}]}]}