{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLINC01748 is a long noncoding RNA that plays a crucial regulatory role in non‐small cell lung cancer (NSCLC). It is significantly overexpressed in NSCLC tissues and cells, with higher levels correlating with poorer patient overall survival. Functional studies demonstrated that knockdown of LINC01748 results in reduced cell proliferation, migration, and invasion while increasing apoptosis in vitro; similar knockdown also led to inhibition of tumor growth in vivo. Mechanistically, LINC01748 acts as a competing endogenous RNA (ceRNA) by sponging microRNA miR‑520a‑5p, which in turn leads to the upregulation of HMGA1—a gene involved in promoting tumor aggressiveness. Rescue experiments reinforced this pathway by showing that miR‑520a‑5p inhibition or HMGA1 overexpression counteracts the suppressive effects imparted by LINC01748 knockdown."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yinling Tan, Fengxia Xu, Lingling Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non‑coding RNA LINC01748 exerts carcinogenic effects in non‑small cell lung cancer cell lines by regulating the microRNA‑520a‑5p/HMGA1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2021.5077"}], "href": "https://doi.org/10.3892/ijmm.2021.5077"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34970695"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34970695"}]}]}]}