{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn thyroid carcinoma, LINC01816 exhibits oncogenic properties by being significantly upregulated relative to normal thyroid tissues. Its overexpression enhances cellular invasion, migration, and epithelial–mesenchymal transition (EMT), all of which contribute to cancer aggressiveness. Mechanistically, LINC01816 functions as a molecular sponge for miR‑134c‑5p, thereby relieving the microRNA’s inhibitory effect on its target, cellular retinoic acid binding protein 2 (CRABP2). The resultant upregulation of CRABP2 promotes the invasive and migratory capabilities of thyroid carcinoma cells, suggesting that targeting the LINC01816/miR‑134c‑5p/CRABP2 signaling axis could provide a novel therapeutic approach. Moreover, the aberrant expression of LINC01816 in various cancer types, as well as its previous association with patient survival in colorectal cancer, underscores its potential broader role in oncogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hongyuan Zhao, Xiaofeng Zhu, Yi Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01816 promotes the migration, invasion and epithelial‑mesenchymal transition of thyroid carcinoma cells by sponging miR‑34c‑5p and regulating CRABP2 expression levels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2021.8032"}], "href": "https://doi.org/10.3892/or.2021.8032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33786631"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33786631"}]}]}]}