{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent work has highlighted the diverse and critical roles of long non‑coding RNAs (lncRNAs) in tumor biology. For example, in bladder cancer, a lncRNA (RP11‑89) was shown to act as a molecular sponge for miR‑129‑5p, thereby upregulating PROM2. PROM2, in turn, promotes cell proliferation, migration, and tumorigenesis by facilitating iron export and reducing ferroptosis‐associated damage. This study underscores how lncRNAs can regulate key cellular processes through microRNA interactions and modulation of downstream effectors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn non‑small cell lung cancer (NSCLC), a different lncRNA—LINC01833—has been implicated in driving malignant behavior through its presence in cancer‑associated fibroblast (CAF)‑derived exosomes. LINC01833 is highly expressed in NSCLC tumor tissues and cells where it promotes tumor cell proliferation, migration, and invasion. Moreover, LINC01833 facilitates M2 macrophage polarization, an alteration of the tumor microenvironment that further supports cancer progression. Mechanistic investigations revealed that LINC01833 functions by sponging miR‑335‑5p, which leads to deregulation of VAPA activity, ultimately enhancing the aggressive traits of NSCLC cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wenjie Luo, Jun Wang, Wenhao Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA RP11-89 facilitates tumorigenesis and ferroptosis resistance through PROM2-activated iron export by sponging miR-129-5p in bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-04296-1"}], "href": "https://doi.org/10.1038/s41419-021-04296-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34728613"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34728613"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jie Chen, Jian-Jun Sun, Ya-Wen Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cancer-associated fibroblasts derived exosomal LINC01833 promotes the occurrence of non-small cell lung cancer through miR-335-5p -VAPA axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem Mol Toxicol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbt.23769"}], "href": "https://doi.org/10.1002/jbt.23769"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39152098"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39152098"}]}]}]}