{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have highlighted the critical role of long noncoding RNAs (lncRNAs) in the development of non‐small cell lung cancer (NSCLC). In particular, LINC01852—previously identified as ENST00000434223—is significantly downregulated in NSCLC tissues compared to adjacent normal tissues, suggesting a potential tumor‐suppressive function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " \n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFunctional investigations in NSCLC cell lines have demonstrated that overexpression of LINC01852 markedly inhibits cell proliferation and migration, while also reversing the epithelial–mesenchymal transition process. These findings underscore the promise of LINC01852 as both a novel diagnostic biomarker and a therapeutic target in the management of NSCLC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaofei Chai, Xiangyun Ye, Yongping Song "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA ENST00000434223 suppressed tumor progression in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-016-4974-5"}], "href": "https://doi.org/10.1007/s13277-016-4974-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26883250"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26883250"}]}]}]}