{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe studies provided focus on the functions of the PEX11 gene family – key regulators of peroxisome abundance, fatty acid metabolism, and cellular homeostasis – rather than on LINC01905. For instance, one study demonstrated that overexpression of PEX11α can drive peroxisome division and that its expression is induced by specific peroxisome proliferating agents, while the identification of a third isoform (PEX11γ) further expanded the understanding of peroxisomal membrane protein involvement in organelle proliferation. These findings underscore the importance of PEX11 proteins in modulating peroxisomal dynamics, though they do not address any function of LINC01905."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a second study, the targeted disruption of Pex11α led to a significant reduction in peroxisome numbers and impaired peroxisomal fatty acid oxidation in the liver, resulting in elevated hepatic triglyceride levels. This investigation links peroxisome biogenesis and function to lipid metabolism and the development of nonalcoholic fatty liver disease. Despite the mechanistic clarity provided for PEX11α function in hepatic lipid homeostasis, there is no mention or evidence supporting a role for LINC01905."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA third study explored renal pathology, revealing that Pex11a deficiency in proximal tubule cells diminishes functional peroxisome abundance, thereby exacerbating tubulointerstitial lesions in models of chronic kidney disease. The protective effect of pharmacologically restoring peroxisome numbers further emphasizes the critical role of PEX11-mediated peroxisomal function in mitigating renal damage. However, similar to the other reports, this work does not investigate or attribute any function to LINC01905."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these studies highlight the essential functions of the PEX11 gene family in peroxisome division, fatty acid oxidation, and tissue homeostasis. Importantly, none of the abstracts provide evidence for a role or function for LINC01905. As such, while the PEX11 proteins are clearly central to peroxisomal regulation, any function of LINC01905 remains to be elucidated by future research.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaoling Li, Eveline Baumgart, Gao-Xiang Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PEX11alpha is required for peroxisome proliferation in response to 4-phenylbutyrate but is dispensable for peroxisome proliferator-activated receptor alpha-mediated peroxisome proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.22.23.8226-8240.2002"}], "href": "https://doi.org/10.1128/MCB.22.23.8226-8240.2002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12417726"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12417726"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Huachun Weng, Xu Ji, Yukiko Naito, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pex11α deficiency impairs peroxisome elongation and division and contributes to nonalcoholic fatty liver in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Endocrinol Metab (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpendo.00425.2012"}], "href": "https://doi.org/10.1152/ajpendo.00425.2012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23169785"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23169785"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Huachun Weng, Xu Ji, Kosuke Endo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pex11a deficiency is associated with a reduced abundance of functional peroxisomes and aggravated renal interstitial lesions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hypertension (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/HYPERTENSIONAHA.114.04094"}], "href": "https://doi.org/10.1161/HYPERTENSIONAHA.114.04094"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25113963"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25113963"}]}]}]}