{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations have revealed that LINC01915 plays a suppressive role in the colorectal cancer microenvironment by impeding the conversion of normal fibroblasts (NFs) into cancer‐associated fibroblasts (CAFs). In clinical samples and cell models, LINC01915 expression was downregulated in cancer tissues and in CAFs compared to NFs, a change that correlated with a poorer prognosis. Mechanistically, LINC01915 functions as a competing endogenous RNA by binding to miR‑92a‑3p, thereby relieving the repression on the miR‑92a‑3p target KLF4. Activated KLF4 subsequently promotes the transcription of CH25H, a factor that reduces the uptake of tumor‐derived extracellular vesicles (EVs) by NFs. This reduction in EV uptake results in decreased NF activation, angiogenesis, and ultimately tumor growth, as demonstrated by both in vitro experiments and in vivo xenograft models."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Minghe Zhou, Shalong Wang, Dongcai Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01915 Facilitates the Conversion of Normal Fibroblasts into Cancer-Associated Fibroblasts Induced by Colorectal Cancer-Derived Extracellular Vesicles through the miR-92a-3p/KLF4/CH25H Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "ACS Biomater Sci Eng (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acsbiomaterials.1c00611"}], "href": "https://doi.org/10.1021/acsbiomaterials.1c00611"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34643375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34643375"}]}]}]}