{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLINC01980 is a long noncoding RNA that has emerged as a potential oncogene in multiple cancers. In esophageal squamous cell carcinoma (ESCC), LINC01980 is significantly upregulated in both the nucleus and cytoplasm, and its high expression correlates with deeper local invasion, lymph node metastasis, and advanced TNM stage. Functional assays have demonstrated that LINC01980 promotes tumor growth by accelerating cell proliferation, preventing apoptosis, and inducing cell cycle progression, potentially through the upregulation of growth arrest and DNA damage inducible 45 alpha (GADD45A). These findings suggest that LINC01980 not only serves as a prognostic biomarker but may also represent a promising therapeutic target for ESCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "In hepatocellular carcinoma (HCC), LINC01980 is similarly found to be overexpressed and is associated with markedly poor overall survival. Mechanistic studies indicate that LINC01980 enhances HCC metastasis by competitively binding to miR-376b-5p, which results in the upregulation of E2F5—a key mediator of epithelial-mesenchymal transition—thus promoting cancer cell migration and invasion. Furthermore, the transcription of LINC01980 is activated by the canonical TGF‑β/SMAD signaling pathway, reinforcing its role in HCC progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shixin Zhang, Yan Liang, Yuanyuan Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of a novel lncRNA LINC01980 promotes tumor growth of esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.03.012"}], "href": "https://doi.org/10.1016/j.bbrc.2019.03.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30935686"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30935686"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jiaqi Sheng, Yiming Luo, Enjun Lv, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01980 induced by TGF-beta promotes hepatocellular carcinoma metastasis via miR-376b-5p/E2F5 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2023.110923"}], "href": "https://doi.org/10.1016/j.cellsig.2023.110923"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37827344"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37827344"}]}]}]}