{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLINC02381 is emerging as a multifunctional lncRNA in cancer, with context‐dependent roles. In colorectal cancer, LINC02381 is downregulated as a result of DNA methylation, and its upregulation suppresses cell viability and proliferation while promoting apoptosis via modulation of the PI3K/Akt pathway and upregulation of PTEN (see abstract 1:."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Conversely, in lung adenocarcinoma, LINC02381 (also termed HMS) is overexpressed and promotes oncogenic phenotypes by enhancing the stability of HOXC10 mRNA through binding with the RNA-binding protein HuR, thus sustaining cancer cell proliferation and colony formation (abstract 2:."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its implications in carcinogenesis, LINC02381 has been implicated in inflammatory and vascular disorders. In rheumatoid arthritis, this lncRNA is upregulated in synovial tissues and fibroblast-like synoviocytes where it functions as a competitive endogenous RNA by sequestering miR-590-5p. This action relieves post-transcriptional repression of MAP2K3, leading to activation of the MAPK signaling cascade, enhanced cell proliferation, and invasion (abstract 3:."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similarly, in atherosclerosis, knockdown of LINC02381 alleviates injury in oxidized LDL-treated endothelial cells by modulating the miR-491-5p/TCF7 axis, thereby protecting against abnormal cellular proliferation (abstract 6:."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional studies hint at broader roles for LINC02381 in other cellular contexts. In human umbilical cord blood-derived mesenchymal stem cells, preliminary evidence supports its involvement in osteogenic differentiation (abstract 4:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", while in endometriosis, LINC02381 might regulate cellular proliferation and invasion by interacting with key regulators such as CTNNB1, suggesting a role in disease pathogenesis (abstract 5:."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Meisam Jafarzadeh, Bahram M Soltani, Masoud Soleimani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetically silenced LINC02381 functions as a tumor suppressor by regulating PI3K-Akt signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochimie (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biochi.2020.02.009"}], "href": "https://doi.org/10.1016/j.biochi.2020.02.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32092325"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32092325"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Priyanka Priyanka, Madhur Sharma, Sanjeev Das, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The lncRNA HMS recruits RNA-binding protein HuR to stabilize the 3'-UTR of HOXC10 mRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jbc.2021.100997"}], "href": "https://doi.org/10.1016/j.jbc.2021.100997"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34302808"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34302808"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jing Wang, Qing Zhao "}, {"type": "b", "children": [{"type": "t", "text": "Linc02381 Exacerbates Rheumatoid Arthritis Through Adsorbing miR-590-5p and Activating the Mitogen-Activated Protein Kinase Signaling Pathway in Rheumatoid arthritis-fibroblast-like synoviocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Transplant (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/0963689720938023"}], "href": "https://doi.org/10.1177/0963689720938023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32608996"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32608996"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xizheng Zhu, Hui Xu, Beijia Chen "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of ox-LDL-induced endothelial cell injury by LINC02381 knockdown through the microRNA-491-5p/transcription factor 7 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immun Inflamm Dis (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/iid3.785"}], "href": "https://doi.org/10.1002/iid3.785"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36988257"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36988257"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Gang Zhao, Wen-Dong Luo, Yong Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC02381, a sponge of miR-21, weakens osteogenic differentiation of hUC-MSCs through KLF12-mediated Wnt4 transcriptional repression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bone Miner Metab (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00774-021-01277-4"}], "href": "https://doi.org/10.1007/s00774-021-01277-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34778905"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34778905"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiaoqing Wang, Peili Wu, Cheng Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Intergenic Non-Protein Coding RNA 02381 Promotes the Proliferation and Invasion of Ovarian Endometrial Stromal Cells through the miR-27b-3p/CTNNB1 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes (Basel) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/genes13030433"}], "href": "https://doi.org/10.3390/genes13030433"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35327987"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35327987"}]}]}]}