{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLong noncoding RNAs (lncRNAs) have emerged as pivotal regulators in cancer progression. Recent studies have illustrated the tumor‐promoting potential of lncRNAs such as MEOX2‐AS1 in cervical cancer, where it enhances proliferation, migration, and invasion via a mechanism involving miR‑143‑3p and VDAC1, and is activated by the transcription factor STAT1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a similar vein, LINC02587 has been identified as differentially expressed across multiple tumor types—including bladder urothelial cancer, glioblastoma, lung adenocarcinoma, lung SCC, and melanoma—with notable aberrations observed in glioma. However, unlike more extensively characterized lncRNAs, the precise functional role and underlying mechanism of LINC02587 in glioma development remain elusive, highlighting the need for further investigation into its potential as a diagnostic biomarker and therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiao-Xing Liu, Qi-Xiu Bao, Yan-Mei Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The promotion of cervical cancer progression by signal transducer and activator of transcription 1-induced up-regulation of lncRNA MEOX2-AS1 as a competing endogenous RNA through miR-143-3p/VDAC1 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1947174"}], "href": "https://doi.org/10.1080/21655979.2021.1947174"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34224325"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34224325"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhengang Wang, Yang Cui, Fanchen Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA methylation-regulated LINC02587 inhibits ferroptosis and promotes the progression of glioma cells through the CoQ-FSP1 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-023-11502-0"}], "href": "https://doi.org/10.1186/s12885-023-11502-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37848823"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37848823"}]}]}]}