{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough neither study directly investigated LINC02694, evidence from both abstracts suggests that genomic regions involved in psychiatric disorders may include regulatory noncoding elements like LINC02694. In the first genome‐wide association study of bipolar disorder in individuals of European and African ancestry (PMID:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", several single‐nucleotide polymorphisms were identified in coding and intergenic regions of the genome. While the study highlighted candidate protein‐coding genes such as NAP5, DPY19L3, NTRK2, ANK3, and others, the presence of intergenic susceptibility loci points to a possible role for long noncoding RNAs—such as LINC02694—in modulating gene expression and neuronal pathways that underpin bipolar disorder.\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA second study, a family‐based genome‐wide association analysis of alcohol-use disorders (PMID:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", similarly identified risk variants in genomic intervals including regions near noncoding genes. Although this study primarily reported strong associations for variants mapped to C15orf53, its findings underscore the importance of noncoding sequences in influencing susceptibility to psychiatric conditions; by extension, LINC02694—a long intergenic noncoding RNA—may function as a regulatory element that affects transcriptional networks and neuronal signaling involved in alcohol dependence and potentially bipolar disorder.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "E N Smith, C S Bloss, J A Badner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study of bipolar disorder in European American and African American individuals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mp.2009.43"}], "href": "https://doi.org/10.1038/mp.2009.43"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19488044"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19488044"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "J-C Wang, T Foroud, A L Hinrichs, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mp.2012.143"}], "href": "https://doi.org/10.1038/mp.2012.143"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23089632"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23089632"}]}]}]}