{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nCurrent evidence underscores a complex regulatory network in which microRNAs play key roles in diverse disease processes. For instance, in lung cancer, microRNA‐876-5p suppresses epithelial-mesenchymal transition (EMT) by directly targeting BMP-4, thereby inhibiting cellular migration, invasion, and metastasis. Although none of the studies explicitly mention LINC02902, the spatial or functional proximity of LINC02902 to microRNA-876 family members suggests that it may serve as an upstream regulator or competing endogenous RNA (ceRNA) that fine-tunes microRNA-876-5p levels and hence modulates the EMT process."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn parallel, investigations into atherosclerosis have revealed that microRNA dysregulation is an important factor driving endothelial cell injury and apoptosis—a key event in the initiation of vascular plaque formation. This observation raises the possibility that LINC02902 might intersect with these microRNA-mediated pathways, potentially influencing endothelial cell survival and the progression of vascular disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, studies in adipocyte biology and insulin resistance demonstrate that microRNA-876-3p critically regulates adiponectin expression and glucose homeostasis. Given that lentiviral inhibition of microRNA-876-3p ameliorates insulin resistance in both cellular and animal models, LINC02902 may similarly contribute to metabolic processes by modulating microRNA-876-3p activity. Thus, LINC02902 could represent a novel molecular node linking oncogenic EMT, vascular dysfunction, and metabolic dysregulation, offering promising avenues for therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Liang Bao, Lei Lv, Jinping Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-876-5p suppresses epithelial-mesenchymal transition of lung cancer by directly down-regulating bone morphogenetic protein 4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biosci (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12038-017-9722-5"}], "href": "https://doi.org/10.1007/s12038-017-9722-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29229885"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29229885"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kaicheng Xu, Peng Liu, Yue Zhao "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of microRNA-876 Induces Endothelial Cell Apoptosis by Suppressing Bcl-Xl in Development of Atherosclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000479271"}], "href": "https://doi.org/10.1159/000479271"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28723693"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28723693"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sujith Rajan, Ganesh Panzade, Ankita Srivastava, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-876-3p regulates glucose homeostasis and insulin sensitivity by targeting adiponectin"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Endocrinol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/JOE-17-0387"}], "href": "https://doi.org/10.1530/JOE-17-0387"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30307150"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30307150"}]}]}]}