{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent findings indicate that LINC03052—referred to as lncRNA799 in the original study—is overexpressed in cervical cancer cells, where it plays a pivotal role in promoting tumorigenic processes, including cell proliferation and the epithelial–mesenchymal transition (EMT). This upregulation correlates with enhanced invasiveness and metastatic potential in cervical cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nMechanistic insights reveal that LINC03052 interacts with the eukaryotic translation initiation factor 4A3 to stabilize the mRNA of transducin (β)-like 1 X-linked receptor 1 (TBL1XR1). This stabilization is critical for reinforcing the interaction between TBL1XR1 and the transcription factor zinc finger E-box-binding homeobox 1 (ZEB1), forming a positive feedback loop in which ZEB1, in turn, transcriptionally activates LINC03052. Through this axis, the lncRNA indirectly enhances EMT and supports the proliferative and invasive behavior of cervical cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nFunctionally, experimental knockdown of LINC03052 resulted in suppressed cell proliferation and inhibited EMT, underscoring its oncogenic role in cervical cancer. These findings suggest that targeting the LINC03052/TBL1XR1/ZEB1 feedback loop could represent a promising therapeutic strategy for managing cervical cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lingmin Liao, Peng Huang, Jiali Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA799/TBL1XR1/ZEB1 Axis Forms a Feedback Loop to Promote the Epithelial-Mesenchymal Transition of Cervical Cancer Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Crit Rev Eukaryot Gene Expr (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1615/CritRevEukaryotGeneExpr.2023049916"}], "href": "https://doi.org/10.1615/CritRevEukaryotGeneExpr.2023049916"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38073440"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38073440"}]}]}]}