{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have established the critical importance of ATP‐binding cassette (ABC) transporters in maintaining cellular homeostasis by mediating the directed efflux of a wide range of molecules – from amyloid‐β peptides and vitamin B12 to cyclic dinucleotides and glutathione conjugates. In several disease models, including Alzheimer’s disease and acute renal injury, altered transporter function (most notably that of ABCC1/MRP1) was shown to change the intracellular accumulation of both physiological and toxic compounds, thereby altering disease progression and cell survival."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional investigations have expanded this view by demonstrating that transporter activity is intertwined with regulation of immune responses, oxidative stress defenses, and lipid as well as steroid metabolism. The compartmentalization of these transporters (for example, their association with lipid rafts in endothelial cells) and their integration with signaling cascades underpin their roles not only in facilitating substrate clearance across the blood–brain and blood–retinal barriers but also in modulating cytokine release and inflammatory cell recruitment in conditions such as autoimmunity, infection, and even hearing loss."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nEmerging evidence now suggests that long intergenic non‐coding RNAs (lincRNAs) might provide an additional layer of regulation for these complex transporter networks. Although none of the studies detailed here focus directly on LINC03100, its putative function may be inferred by analogy. In view of the diverse roles of ABC transporters in neuroprotection, drug resistance, and oxidative stress control—as well as their regulation by intricate intracellular signaling events—LINC03100 is postulated to act as a regulatory RNA modulator that fine‐tunes transporter expression or activity. Such regulation may influence cellular responses to endogenous toxic metabolites and exogenous insults, thereby impacting processes as varied as neuronal survival, immune activation, and tissue detoxification. This potential role is particularly intriguing given the dynamic changes observed upon altered transporter function in models of neurodegeneration, inflammation, and even noise‐induced auditory damage."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "25", "end_ref": "37"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "C Fernetti, L Pascolo, E Podda, et al. 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