{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINCMD1 is a long non‐protein coding region located near the IL17 locus that has been implicated as a potential genetic factor contributing to osteoarthritis risk. In the study of Croatian patients with large‐joint osteoarthritis, variations in LINCMD1 (along with nearby regulatory microRNAs such as miR‑133b and miR‑206) were suggested to influence joint‐dependent disease susceptibility. Although its precise molecular function has not yet been elucidated, LINCMD1 is postulated to modulate local gene regulation in the inflammatory milieu of joint tissues, potentially affecting cytokine responses mediated by IL17. This genetic region may therefore underlie, at least in part, disparate pathophysiological mechanisms between hip and knee osteoarthritis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "RandiK Eftedal, Goran Vrgoc, Zdravko Jotanovic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alternative Interleukin 17A/F Locus Haplotypes are Associated With Increased Risk to Hip and Knee Osteoarthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Orthop Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jor.24334"}], "href": "https://doi.org/10.1002/jor.24334"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31042000"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31042000"}]}]}]}