{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent findings have revealed that LINGO1‐AS1 is one of the key long noncoding RNAs (lncRNAs) whose expression is significantly downregulated in dilated cardiomyopathy (DCM) compared with normal heart tissues. Notably, LINGO1‐AS1 was identified within a gene coexpression network module enriched for genes linked to neurotransmitter secretion—a process that can modulate cardiac electrophysiology and function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nIn the study, weighted gene coexpression network analysis (WGCNA) highlighted that downregulation of LINGO1‐AS1, along with other lncRNAs, correlated with the progression of DCM. The implication is that the reduction of LINGO1‐AS1 expression may alter neurotransmitter secretion-related pathways, potentially affecting heart contraction and blood circulation mechanisms that underlie DCM pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nMoreover, the association of LINGO1‐AS1 with networks governing neurotransmitter release suggests that it might be a critical diagnostic biomarker and a therapeutic target in DCM. Its suppressed expression may contribute to the complex molecular alterations seen in failing hearts, thereby offering a window into potential intervention strategies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhibing Qiu, Bin Ye, Li Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of AC061961.2, LING01-AS1, and RP11-13E1.5 is associated with dilated cardiomyopathy progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.27247"}], "href": "https://doi.org/10.1002/jcp.27247"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30203513"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30203513"}]}]}]}