{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LIPE‐AS1 is a long non‐coding RNA that has been implicated in several biological processes and malignancies. In the context of the DNA damage response in lung and liver cancer cells, LIPE‐AS1 expression was found to be markedly downregulated while its antisense partner, CEACAM1, was concurrently upregulated; however, detailed mechanistic studies indicated that neither transcript‐dependent nor transcription‐dependent regulatory mechanisms could explain this inverse correlation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In head and neck squamous cell carcinoma, LIPE‐AS1 emerged as one of nine ferroptosis‐related lncRNAs whose expression contributed to a prognostic signature; patients exhibiting a high risk score based on this signature had significantly shorter overall survival, and the implicated lncRNAs were enriched in pathways such as phagocytosis, metabolism, and chemokine signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In addition, preliminary characterization of LIPE‐AS1 in the arena of adipogenesis suggests that it may play a role in the regulation of adipocyte differentiation or fat metabolism, further underscoring its diverse functional repertoire."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, LIPE‐AS1 has been incorporated into prognostic models based on immune‐related long non‐coding RNAs in cervical cancer, supporting its potential utility as a biomarker for patient stratification based on immune contexture and overall prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies indicate that LIPE‐AS1 may serve multifaceted roles in cancer biology, acting as a potential prognostic indicator and possibly participating in the regulation of processes such as the DNA damage response, ferroptosis, adipogenesis, and immune modulation. Further research is warranted to elucidate the precise molecular mechanisms through which LIPE‐AS1 exerts these varied effects.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ashish Goyal, Evgenij Fiškin, Tony Gutschner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A cautionary tale of sense-antisense gene pairs: independent regulation despite inverse correlation of expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkx952"}], "href": "https://doi.org/10.1093/nar/gkx952"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29059299"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29059299"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Rui Lu, Zhiyong Li, Shucheng Yin "}, {"type": "b", "children": [{"type": "t", "text": "Constructing a Ferroptosis-related Long Non-coding RNA Signature to Predict the Prognostic of Head and Neck Squamous Cell Carcinoma Patients by Bioinformatic Analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Genet (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10528-021-10176-2"}], "href": "https://doi.org/10.1007/s10528-021-10176-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35098409"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35098409"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Alyssa Thunen, Deirdre La Placa, Zhifang Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of lncRNA LIPE-AS1 in adipogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Adipocyte (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21623945.2021.2013415"}], "href": "https://doi.org/10.1080/21623945.2021.2013415"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34957921"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34957921"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jinhui Liu, Yinghui Liu, Feng Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive study of a novel immune-related lncRNA for prognosis and drug treatment of cervical squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Transl Res (2021)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34786106"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34786106"}]}]}]}