{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn normal epithelial cells, the long noncoding RNA LITATS1 (also known as LINC01137 or ZC3H12A-DT) acts as a pivotal epithelial gatekeeper by restraining the epithelial‐to‐mesenchymal transition (EMT) that underpins cancer progression. Functionally, LITATS1 is induced by TGF‑β and protects epithelial integrity by attenuating TGF‑β/SMAD signaling. It achieves this by enhancing the polyubiquitination and proteasomal degradation of the TGF‑β type I receptor (TβRI) through its interaction with the E3 ubiquitin ligase SMURF2, sequestering SMURF2 in the cytoplasm. This mechanism curbs TGF‑β–induced cellular migration, extravasation, and EMT, and its reduced expression in lung adenocarcinoma correlates with improved prognosis in patients with breast and non‑small cell lung cancers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Additionally, while LITATS1 (LINC01137) is emerging as a relevant long noncoding RNA in the context of cancer initiation and progression, its precise functional role in the development of oral squamous cell carcinoma (OSCC) remains to be determined."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chuannan Fan, Qian Wang, Thomas B Kuipers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LITATS1 suppresses TGF-β-induced EMT and cancer cell plasticity by potentiating TβRI degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embj.2022112806"}], "href": "https://doi.org/10.15252/embj.2022112806"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36994542"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36994542"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yong Du, Haiyan Yang, Yue Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC01137 contributes to oral squamous cell carcinoma development and is negatively regulated by miR-22-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Oncol (Dordr) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13402-021-00586-0"}], "href": "https://doi.org/10.1007/s13402-021-00586-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33797737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33797737"}]}]}]}