{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nWhile the query specifically mentions LMNTD2‐AS1, the provided abstract"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "does not report any findings regarding LMNTD2‐AS1. Instead, it focuses on the essential role of the SCAPER protein in gonadal development and gametogenesis. In this study, mutations in SCAPER cause a multisystemic disorder characterized by retinal degeneration, intellectual disability, and notably, significant reproductive defects in mice. In the testes, loss of SCAPER results in severely impaired spermatogenesis—with seminiferous tubules lacking proper germ cell development—and in ovaries, a reduction of primordial and antral follicles coupled with an increase in atretic follicles is observed.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn wild‐type animals, SCAPER is widely expressed in spermatogonial stem cells, differentiating germ cells, and Sertoli cells in the male gonad, as well as in granulosa cells and oocytes in the female ovary. The reproductive abnormalities seen in mutant mice are hypothesized to stem from a disruption of SCAPER’s interaction with the cyclin A/Cdk2 complex, emphasizing its role in the cell cycle regulation required for normal reproductive function. Thus, while the function of LMNTD2‐AS1 remains unaddressed in this work, the study provides important insights into how SCAPER modulates cellular processes crucial for fertility.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yasmin Tatour, Hadas Bar-Joseph, Ruth Shalgi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Male sterility and reduced female fertility in SCAPER-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddaa113"}], "href": "https://doi.org/10.1093/hmg/ddaa113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32510560"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32510560"}]}]}]}