{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have implicated long noncoding RNAs (lncRNAs) as key regulators of tumor progression by functioning in competing endogenous RNA (ceRNA) networks. In particular, LMO7‐AS1 has emerged as a prognostic biomarker in cancer. In colorectal cancer, integrated analyses constructing ceRNA regulatory networks and immune‐related lncRNA signatures have identified panels of lncRNAs that strongly correlate with patient survival and cancer‐related signaling pathways. Although one study validated a novel lncRNA within a four‐lncRNA prognostic model for CRC, the overall approach highlights how lncRNA‐mediated ceRNA interactions can modulate oncogenic processes and help stratify patients by risk."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in Wilms’ tumor, the integration of lncRNA, microRNA, and mRNA expression profiles into a ceRNA network revealed that high expression of LMO7‐AS1, alongside several other dysregulated lncRNAs, is significantly associated with poorer overall survival. This finding suggests that LMO7‐AS1 may function as an oncogenic regulator—likely by sequestering tumor‐suppressive miRNAs and thereby dysregulating downstream mRNA targets involved in cell proliferation and survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Collectively, these studies underscore the potential of LMO7‐AS1 both as a prognostic indicator and as a functional player within ceRNA networks that influence tumorigenesis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhi-Dong Yang, Hui Kang "}, {"type": "b", "children": [{"type": "t", "text": "Exploring prognostic potential of long noncoding RNAs in colorectal cancer based on a competing endogenous RNA network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Gastroenterol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3748/wjg.v26.i12.1298"}], "href": "https://doi.org/10.3748/wjg.v26.i12.1298"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32256018"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32256018"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Fengxia Qin, Houxi Xu, Guoli Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Prognostic Model Based on the Immune-Related lncRNAs in Colorectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2021.658736"}], "href": "https://doi.org/10.3389/fgene.2021.658736"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33959151"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33959151"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hong Zheng, Bai-Hui Li, Chang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive Analysis of lncRNA-Mediated ceRNA Crosstalk and Identification of Prognostic Biomarkers in Wilms' Tumor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/4951692"}], "href": "https://doi.org/10.1155/2020/4951692"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32149111"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32149111"}]}]}]}