| Name | lunapark, ER junction formation factor |
| Description | Enables identical protein binding activity. Involved in endoplasmic reticulum tubular network maintenance and positive regulation of endoplasmic reticulum tubular network organization. Located in endoplasmic reticulum tubular network membrane and nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LNPK (Lunapark) proteins have emerged as critical multifunctional regulators that operate at both the architectural and regulatory levels across various organisms. In mammalian and yeast cells, LNPK localizes predominantly at three‐way junctions within the endoplasmic reticulum (ER) network, where it interacts with membrane fusion proteins (such as atlastin) and ER‐shaping factors (like the reticulon family) to balance tubule fusion and polygonal network formation, thereby maintaining ER stability and proper morphology (–."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " In plants, homologues of LNPK (for example, AtLNP1/AtLNP2 or LNPA/LNPB) do not strictly concentrate at junctions; rather, they are broadly distributed in the ER and are essential for proper formation of cisternae and the even distribution of membranes. Mutations or simultaneous loss of these proteins lead to disrupted network organization and the appearance of aberrant spherical ER structures (–."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Beyond their roles in ER morphology, genomic studies have implicated LNPK‐containing regulatory domains in developmental processes: a conserved enhancer near LNPK helps coordinate the expression of multiple developmental genes (such as those in the HOXD cluster) crucial for limb and central nervous system formation (–."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, genetic association studies have revealed that sequence variations in LNPK (also annotated as KIAA1715) are linked to periodontitis‐related traits in humans as well as to morphological features in livestock like polycerate (multi‐horned) phenotypes in sheep (–."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "François Spitz, Federico Gonzalez, Denis Duboule "}, {"type": "b", "children": [{"type": "t", "text": "A global control region defines a chromosomal regulatory landscape containing the HoxD cluster."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0092-8674(03)00310-6"}], "href": "https://doi.org/10.1016/s0092-8674(03"}, {"type": "t", "text": "00310-6) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12732147"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12732147"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shuliang Chen, Peter Novick, Susan Ferro-Novick "}, {"type": "b", "children": [{"type": "t", "text": "ER network formation requires a balance of the dynamin-like GTPase Sey1p and the Lunapark family member Lnp1p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb2523"}], "href": "https://doi.org/10.1038/ncb2523"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22729086"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22729086"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xin Zhou, Yu He, Xiaofang Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reciprocal regulation between lunapark and atlastin facilitates ER three-way junction formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Protein Cell (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13238-018-0595-7"}], "href": "https://doi.org/10.1007/s13238-018-0595-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30498943"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30498943"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Haruko Ueda, Natsumi Ohta, Yoshitaka Kimori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endoplasmic Reticulum (ER) Membrane Proteins (LUNAPARKs) are Required for Proper Configuration of the Cortical ER Network in Plant Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Plant Cell Physiol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/pcp/pcy137"}], "href": "https://doi.org/10.1093/pcp/pcy137"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30010972"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30010972"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Verena Kriechbaumer, Emily Breeze, Charlotte Pain, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arabidopsis Lunapark proteins are involved in ER cisternae formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "New Phytol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/nph.15228"}], "href": "https://doi.org/10.1111/nph.15228"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29797722"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29797722"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Teresa Yang, Bin Cheng, James M Noble, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Replication of gene polymorphisms associated with periodontitis-related traits in an elderly cohort: the Washington Heights/Inwood Community Aging Project Ancillary Study of Oral Health."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Periodontol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcpe.13605"}], "href": "https://doi.org/10.1111/jcpe.13605"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35179257"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35179257"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xue Ren, Guang-Li Yang, Wei-Feng Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genome-wide association study identifies a genomic region for the polycerate phenotype in sheep (Ovis aries)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep21111"}], "href": "https://doi.org/10.1038/srep21111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26883901"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26883901"}]}]}]}
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| NCBI Gene ID | 80856 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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LNPK has 913 functional associations with biological entities spanning 6 categories (functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 29 datasets.
Click the + buttons to view associations for LNPK from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| CellMarker Gene-Cell Type Associations | cell types associated with LNPK gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of LNPK gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing LNPK protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with LNPK protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by LNPK gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Curated Gene-Disease Association Evidence Scores 2025 | diseases involving LNPK gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with LNPK gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with LNPK gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with LNPK gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with LNPK gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving LNPK gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving LNPK gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing LNPK protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing LNPK protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of LNPK gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of LNPK gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of LNPK gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| IMPC Knockout Mouse Phenotypes | phenotypes of mice caused by LNPK gene knockout from the IMPC Knockout Mouse Phenotypes dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by LNPK gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of LNPK gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of LNPK gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of LNPK gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of LNPK gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of LNPK gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of LNPK gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of LNPK gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of LNPK protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of LNPK protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with LNPK protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
