{"type": "root", "children": [{"type": "t", "text": "<head>\n <meta charset=\"utf-8\">\n <title>LNX1‐AS1 Function in Lung Cancer</title>\n </head>\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Recent integrative analyses of lung cancer have identified the long noncoding RNA LNX1‐AS1 as a component of a competing endogenous RNA (ceRNA) network implicated in non–small cell lung cancer (NSCLC) prognosis. In one study, LNX1‐AS1 was among several lncRNAs significantly associated with overall survival, suggesting that it may participate in the regulation of gene expression by “sponging” microRNAs and thereby modulating the levels of target mRNAs involved in tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although the precise molecular mechanisms by which LNX1‐AS1 influences NSCLC remain to be fully elucidated, its inclusion in the ceRNA network points to a potential role in affecting critical oncogenic pathways. In parallel, integrated analyses of noncoding variations in lung squamous cell carcinoma (LUSC) have underscored the broader significance of lncRNAs as biomarkers and therapeutic candidates in lung cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Together, these findings highlight the clinical relevance of LNX1‐AS1 as a prognostic factor and a possible target for future therapeutic interventions in lung cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaoyuan Wang, Hang Yin, Luquan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The construction and analysis of the aberrant lncRNA-miRNA-mRNA network in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Thorac Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.21037/jtd.2019.05.69"}], "href": "https://doi.org/10.21037/jtd.2019.05.69"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31285869"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31285869"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jinfeng Ning, Fengjiao Wang, Kaibin Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterizing the Copy Number Variation of Non-Coding RNAs Reveals Potential Therapeutic Targets and Prognostic Markers of LUSC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2021.779155"}], "href": "https://doi.org/10.3389/fgene.2021.779155"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34925461"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34925461"}]}]}]}