{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LOC102723475 is emerging as a novel gene implicated in tumor biology, with initial evidence suggesting that its dysregulation may contribute to remodeling of the tumor microenvironment through modulation of collagen‐related pathways. In studies of esophageal squamous cell carcinoma (ESCC), altered expression of collagen family genes has been linked to processes such as tumor growth, epithelial–mesenchymal transition, and poor patient survival, with key signaling cascades (e.g., PI3K/Akt/mTOR and p53) mediating these effects."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although not detailed extensively in every report, LOC102723475 appears to be part of the broader network of genes influencing extracellular matrix composition and collagen deposition. Its integration into gene expression and survival prediction models underscores its potential as a diagnostic and prognostic biomarker in ESCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Together, these findings suggest that LOC102723475 may modulate critical cellular processes through its impact on collagen gene networks and related signaling pathways; however, further functional studies are warranted to fully elucidate its molecular mechanism and clinical significance.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jieling Li, Xiao Wang, Kai Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The clinical significance of collagen family gene expression in esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.7705"}], "href": "https://doi.org/10.7717/peerj.7705"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31598423"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31598423"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Malena P Pantou, Polyxeni Gourzi, Dimitrios Degiannis "}, {"type": "b", "children": [{"type": "t", "text": "The potential presence of the highly similar paralogue gene KCNE1B blurs the genetic basis of KCNE1-LQTS patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41431-019-0389-2"}], "href": "https://doi.org/10.1038/s41431-019-0389-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30936463"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30936463"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Marta Diñeiro, Guadalupe A Cifuentes, Raquel Capín, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sequencing results from multiple individuals of different ethnicities strongly question the existence of the KCNE1B pseudogene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41431-019-0502-6"}], "href": "https://doi.org/10.1038/s41431-019-0502-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31527855"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31527855"}]}]}]}