{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LOC102723655 is an uncharacterized gene identified within the Identical Repeated Backbone (IRB) of the human genome—a collection of 100% identical repeats (≥300 bp) that are widely distributed and enriched for structural elements such as common repeats, segmental duplications, and genes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although its specific function has not yet been fully elucidated, its inclusion in the IRB suggests that LOC102723655 is located in a dynamic genomic region that is frequently implicated in non-allelic homologous recombination (NAHR) events. Such regions are known to underlie gene copy-number polymorphisms and structural variations—including copy-number variants (CNVs)—that can influence genomic stability and contribute to genomic disorders. Thus, LOC102723655 may play a role, direct or indirect, in processes leading to genomic rearrangements and gene remodeling, marking it as a candidate for further investigation in the context of genome evolution and disease-associated structural variation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Cinthya J Zepeda-Mendoza, Tzitziki Lemus, Omar Yáñez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identical repeated backbone of the human genome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2164-11-60"}], "href": "https://doi.org/10.1186/1471-2164-11-60"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20096123"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20096123"}]}]}]}