{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNA LPP‐AS2 has emerged as an important regulator of tumorigenesis in several cancer types. In glioma, LPP‐AS2 is significantly upregulated and its high expression is associated with poor clinical prognosis. Functionally, LPP‐AS2 acts as a competing endogenous RNA (ceRNA) by sponging miR‐7-5p, which in turn de-represses EGFR expression and activates the downstream PI3K/AKT/c-MYC signaling cascade. Notably, c-MYC further enhances LPP‐AS2 transcription through direct binding to its promoter, establishing a positive feedback loop that amplifies oncogenic signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond glioma, LPP‐AS2 has also been identified as a component of prognostic signatures in other cancers. For instance, in osteosarcoma, LPP‐AS2 is among a panel of metabolism‐related lncRNAs correlated with adverse patient outcomes, suggesting its role in the regulation of metabolic pathways critical for tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in soft tissue sarcoma, LPP‐AS2 is part of a recurrent ceRNA network associated with overall survival and disease recurrence, further underscoring its function in oncogenic regulatory circuits."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings highlight that LPP‐AS2 serves as an oncogenic lncRNA by mediating regulatory networks that promote tumor cell proliferation, invasion, and survival, thereby representing a promising biomarker and potential therapeutic target across multiple cancer types.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaoming Zhang, Wanxiang Niu, Maolin Mu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LPP-AS2 promotes glioma tumorigenesis via miR-7-5p/EGFR/PI3K/AKT/c-MYC feedback loop."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-020-01695-8"}], "href": "https://doi.org/10.1186/s13046-020-01695-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32962742"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32962742"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xingyin Chen, Zhengyun Ye, Pan Lou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive analysis of metabolism-related lncRNAs related to the progression and prognosis in osteosarcoma from TCGA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Orthop Surg Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13018-021-02647-4"}], "href": "https://doi.org/10.1186/s13018-021-02647-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34425868"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34425868"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Runzhi Huang, Tong Meng, Rui Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The construction and analysis of tumor-infiltrating immune cell and ceRNA networks in recurrent soft tissue sarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.102424"}], "href": "https://doi.org/10.18632/aging.102424"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31739284"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31739284"}]}]}]}