{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have increasingly implicated the gene FAM84A in a variety of biological processes that influence cell behavior and disease progression. In several cancer types—including colorectal, liver, and thyroid cancers—FAM84A is frequently up‐regulated, where its increased expression appears to promote cell motility, migration, and epithelial–mesenchymal transition. In colorectal cancer cells, ectopic expression of FAM84A enhanced motility and was correlated with phosphorylation‐dependent changes in cell morphology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In liver tumor models promoted by prolonged phenobarbital exposure, FAM84A was identified as a transcriptional target of the nuclear xenobiotic receptor CAR, with its up‐regulation corresponding to increased cell migration during tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In papillary thyroid carcinoma, elevated levels of FAM84A were associated with larger tumor size, increased lymph node metastasis, and advanced disease stage; mechanistically, FAM84A promoted tumor development by potentiating the epithelial–mesenchymal transition and Wnt/β‐catenin signaling pathways, with its expression negatively regulated by miR-874-3p."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its roles in cancer, genetic variants located upstream of FAM84A have been linked to salt sensitivity of blood pressure, suggesting that the gene may also impact cardiovascular regulatory mechanisms."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Its regulation by microRNAs is further evidenced in studies in the reproductive system where, for example, negative regulation by miR-215 in chicken testicular tissue correlates with differences in sperm motility, implicating FAM84A in spermatogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Additional investigations have identified FAM84A as part of biomarker panels for infectious and inflammatory conditions. In bovine paratuberculosis, for instance, FAM84A is overexpressed in diffuse lesions, suggesting a potential role in modulating cell migration within inflamed tissues."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Variations in DNA methylation at the FAM84A locus during early postnatal life have also been associated with trajectories in body mass index, positing FAM84A as a candidate mediator linking early nutritional exposures (such as exclusive breastfeeding) to later metabolic outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Moreover, FAM84A has been identified as a novel autoantigen in inflammatory bowel disease, suggesting that aberrant immune recognition of this protein might contribute to disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings underscore a multifaceted role for FAM84A in regulating cell motility and invasion, modulating signaling pathways, and potentially influencing immune as well as metabolic responses. Whether acting as a facilitator of tumor progression or serving as an informative biomarker in non-neoplastic conditions, FAM84A emerges as a promising molecular target for future diagnostic and therapeutic strategies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Takaaki Kobayashi, Tadahiko Masaki, Masanori Sugiyama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A gene encoding a family with sequence similarity 84, member A (FAM84A) enhanced migration of human colon cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2006)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16820875"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16820875"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hiroki Kamino, Yuichi Yamazaki, Kosuke Saito, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear receptor CAR-regulated expression of the FAM84A gene during the development of mouse liver tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2011.980"}], "href": "https://doi.org/10.3892/ijo.2011.980"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21424122"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21424122"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yu Ding, Luyao Wu, Xi Zhuang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The direct miR-874-3p-target FAM84A promotes tumor development in papillary thyroid cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.12941"}], "href": "https://doi.org/10.1002/1878-0261.12941"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33751775"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33751775"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hao Mei, Dongfeng Gu, James E Hixson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide linkage and positional association study of blood pressure response to dietary sodium intervention: the GenSalt Study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Epidemiol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/aje/kws290"}], "href": "https://doi.org/10.1093/aje/kws290"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22865701"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22865701"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kai Xing, Mengjin Gao, Xue Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An integrated analysis of testis miRNA and mRNA transcriptome reveals important functional miRNA-targets in reproduction traits of roosters."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.repbio.2020.03.003"}], "href": "https://doi.org/10.1016/j.repbio.2020.03.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32561231"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32561231"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Cristina Blanco Vázquez, Marta Alonso-Hearn, Ramón A Juste, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Detection of latent forms of Mycobacterium avium subsp. paratuberculosis infection using host biomarker-based ELISAs greatly improves paratuberculosis diagnostic sensitivity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0236336"}], "href": "https://doi.org/10.1371/journal.pone.0236336"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32881863"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32881863"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Laurent Briollais, Denis Rustand, Catherine Allard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA methylation mediates the association between breastfeeding and early-life growth trajectories."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Epigenetics (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13148-021-01209-z"}], "href": "https://doi.org/10.1186/s13148-021-01209-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34937578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34937578"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Nathalie Vermeulen, Katrijn Op de Béeck, Severine Vermeire, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a novel autoantigen in inflammatory bowel disease by protein microarray."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Inflamm Bowel Dis (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ibd.21508"}], "href": "https://doi.org/10.1002/ibd.21508"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21560193"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21560193"}]}]}]}