{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LRATD2, also known by its alternative symbol FAM84B, has emerged as an important oncogenic factor in multiple cancer types. Experimental studies show that LRATD2/FAM84B plays a dual role. On one hand, its protein contains proline‐rich domains that contribute to the regulation of anterograde vesicular trafficking, thereby influencing the efficient delivery of cargo proteins within the secretory pathway (1,2). On the other hand, genomic analyses have demonstrated that LRATD2 is frequently amplified and overexpressed in diverse malignancies – including esophageal squamous cell carcinoma, breast cancer, glioma, and prostate cancer – where its elevated expression is linked to increased cell proliferation, migration, invasion, and overall tumor aggressiveness (3–7). Functional inhibition of LRATD2 in several cellular models resulted in marked suppression of tumor cell growth and a decrease in the activation of oncogenic signaling cascades such as the Akt/GSK-3β/β-catenin pathway, highlighting its contribution to cancer progression (4,8). In addition, genetic studies within the 8q24 susceptibility region have shown that LRATD2 is often co-amplified with the MYC oncogene and that specific variants in the LRATD2 locus are associated with increased cancer risk and more advanced disease stages (3,9–11). Finally, proteomic profiling in the context of targeted therapies also indicates that modulation of LRATD2 expression may contribute to therapeutic responses, suggesting that it represents a promising candidate for further evaluation both as a prognostic biomarker and as a potential therapeutic target (12).\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n <small>\n (1)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "; (2)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "; (3)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "; (4)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "; (5)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "; (6)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "; (7)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "; (8)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "; (9)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "; (10)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "; (11)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "; (12)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "</small>\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yan Huang, Haidi Yin, Baiying Li, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Deletion of the murine ortholog of the 8q24 gene desert has anti-cancer effects in transgenic mammary cancer models."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-018-5109-8"}], "href": "https://doi.org/10.1186/s12885-018-5109-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30526553"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30526553"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Minjuan Wang, Chengliang Li, Wei Shi "}, {"type": "b", "children": [{"type": "t", "text": "FAM84B acts as a tumor promoter in human glioma via affecting the Akt/GSK-3β/β-catenin pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biofactors (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/biof.1727"}], "href": "https://doi.org/10.1002/biof.1727"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33759248"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33759248"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zhe Dong, Shengnan Pei, Yan Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Hub Genes in Gastric Cancer with High Heterogeneity Based on Weighted Gene Co-Expression Network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Crit Rev Eukaryot Gene Expr (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1615/CritRevEukaryotGeneExpr.2020028305"}], "href": "https://doi.org/10.1615/CritRevEukaryotGeneExpr.2020028305"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32558489"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32558489"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Nicola J Camp, James M Farnham, Kristina Allen-Brady, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Statistical recombinant mapping in extended high-risk Utah pedigrees narrows the 8q24 prostate cancer locus to 2.0 Mb."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prostate (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pros.20631"}], "href": "https://doi.org/10.1002/pros.20631"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17654497"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17654497"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Anitha Kamath, Harold Tara, Bixia Xiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Double-minute MYC amplification and deletion of MTAP, CDKN2A, CDKN2B, and ELAVL2 in an acute myeloid leukemia characterized by oligonucleotide-array comparative genomic hybridization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Genet Cytogenet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cancergencyto.2008.02.011"}], "href": "https://doi.org/10.1016/j.cancergencyto.2008.02.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18503831"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18503831"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Meijun Du, Tiezheng Yuan, Kala F Schilter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prostate cancer risk locus at 8q24 as a regulatory hub by physical interactions with multiple genomic loci across the genome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddu426"}], "href": "https://doi.org/10.1093/hmg/ddu426"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25149474"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25149474"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Fang Wang, Caixia Cheng, Xinhui Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevated FAM84B promotes cell proliferation via interacting with NPM1 in esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Discov (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41420-022-00984-9"}], "href": "https://doi.org/10.1038/s41420-022-00984-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35396552"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35396552"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Na-na Wang, Jian-ye Wang, Xiao-hong Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Association of TET2, LMTK2 and FAM84B gene expression with prostate cancer risk in Chinese patients]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Zhong Liu Za Zhi (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.issn.0253-3766.2013.04.005"}], "href": "https://doi.org/10.3760/cma.j.issn.0253-3766.2013.04.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23985253"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23985253"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Julian Canisius, Andrea Wagner, Eva Christina Bunk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of decitabine-targeted oncogenes in meningiomas in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosurg Rev (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10143-022-01789-1"}], "href": "https://doi.org/10.1007/s10143-022-01789-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35445910"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35445910"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Dongweon Song, Raghothama Chaerkady, Aik Choon Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Antitumor activity and molecular effects of the novel heat shock protein 90 inhibitor, IPI-504, in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Ther (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1535-7163.MCT-08-0508"}], "href": "https://doi.org/10.1158/1535-7163.MCT-08-0508"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18852131"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18852131"}]}]}]}