LRCOL1 Gene

Name	leucine rich colipase-like 1
Description	Predicted to enable enzyme activator activity. Predicted to be involved in digestion and lipid catabolic process. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The study by"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "performed a genome‐wide investigation of methylated mRNAs and lncRNAs in the ovaries of sheep with contrasting fecundity. In doing so, it identified several methylated lncRNAs—as exemplified by TTC26, MYH15, and NYAP1—that appeared to be key regulatory hubs within co‐expression networks and that may influence biological pathways such as thyroid hormone synthesis and tight junction formation. Although the abstract does not explicitly mention or characterize LRCOL1, no direct functional evidence for LRCOL1 in relation to sheep prolificacy is provided. Thus, based solely on this report, the specific role of LRCOL1 remains undetermined. Nonetheless, the broader findings suggest that methylated lncRNAs can serve as critical regulators in the reproductive processes governing sheep fecundity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiangyang Miao, Qingmiao Luo, Huijing Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An Integrated Analysis of miRNAs and Methylated Genes Encoding mRNAs and lncRNAs in Sheep Breeds with Different Fecundity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Physiol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fphys.2017.01049"}], "href": "https://doi.org/10.3389/fphys.2017.01049"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29326596"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29326596"}]}]}]}
Proteins	LRCL1_HUMAN
NCBI Gene ID	100507055
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

LRCOL1 has 1,998 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 46 datasets.

Click the + buttons to view associations for LRCOL1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

LRCOL1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of LRCOL1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of LRCOL1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of LRCOL1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of LRCOL1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of LRCOL1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of LRCOL1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of LRCOL1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of LRCOL1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of LRCOL1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of LRCOL1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with LRCOL1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of LRCOL1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with LRCOL1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at LRCOL1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of LRCOL1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of LRCOL1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing LRCOL1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of LRCOL1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of LRCOL1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	transcription factor perturbations changing expression of LRCOL1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Viral Infections	virus perturbations changing expression of LRCOL1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
	GO Biological Process Annotations 2015	biological processes involving LRCOL1 gene from the curated GO Biological Process Annotations 2015 dataset.
	GO Cellular Component Annotations 2015	cellular components containing LRCOL1 protein from the curated GO Cellular Component Annotations 2015 dataset.
	GO Molecular Function Annotations 2015	molecular functions performed by LRCOL1 gene from the curated GO Molecular Function Annotations 2015 dataset.
	GTEx eQTL 2025	SNPs regulating expression of LRCOL1 gene from the GTEx eQTL 2025 dataset.
	GTEx Tissue Gene Expression Profiles	tissues with high or low expression of LRCOL1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
	GTEx Tissue Gene Expression Profiles 2023	tissues with high or low expression of LRCOL1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
	GTEx Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of LRCOL1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
	GWAS Catalog SNP-Phenotype Associations 2025	phenotypes associated with LRCOL1 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
	InterPro Predicted Protein Domain Annotations	protein domains predicted for LRCOL1 protein from the InterPro Predicted Protein Domain Annotations dataset.
	JASPAR Predicted Human Transcription Factor Targets 2025	transcription factors regulating expression of LRCOL1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
	JASPAR Predicted Mouse Transcription Factor Targets 2025	transcription factors regulating expression of LRCOL1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
	JASPAR Predicted Transcription Factor Targets	transcription factors regulating expression of LRCOL1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	cell lines with high or low copy number of LRCOL1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
	MGI Mouse Phenotype Associations 2023	phenotypes of transgenic mice caused by LRCOL1 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
	MotifMap Predicted Transcription Factor Targets	transcription factors regulating expression of LRCOL1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	drug perturbations changing expression of LRCOL1 gene from the NIBR DRUG-seq U2OS MoA Box dataset.
	PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of LRCOL1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations	gene perturbations changing expression of LRCOL1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles	cell types and tissues with high or low DNA methylation of LRCOL1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
	Rummagene Transcription Factor Associations 2026	transcription factors regulating expression of LRCOL1 gene from the Rummagene Transcription Factor Associations 2026 dataset.
	RummaGEO Drug Perturbation Signatures	drug perturbations changing expression of LRCOL1 gene from the RummaGEO Drug Perturbation Signatures dataset.
	RummaGEO Gene Perturbation Signatures	gene perturbations changing expression of LRCOL1 gene from the RummaGEO Gene Perturbation Signatures dataset.
	Tabula Sapiens Gene-Cell Associations	cell types with high or low expression of LRCOL1 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset.
	TargetScan Predicted Nonconserved microRNA Targets	microRNAs regulating expression of LRCOL1 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	tissues co-occuring with LRCOL1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.