{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Although none of the provided abstracts examine LRIT2 directly, a careful synthesis of the studies suggests that LRIT2 is most likely a member of the extracellular leucine‐rich repeat (eLRR) protein family, a group that has been implicated in mediating protein–ligand interactions important for neural development, cell–cell communication, and innate immunity. For instance, genome‐wide investigations into complex conditions such as late‐onset Alzheimer disease have identified a number of novel loci that may modulate neurodegenerative risk (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "and."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In parallel, cataloguing studies of eLRR proteins highlight the role of these motifs in the development and specification of neuronal connectivity and in mediating immune responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Furthermore, epigenetic analyses of the retina, a well‐characterized neural tissue, demonstrate that genes with specialized expression signatures during maturation may share regulatory architectures with those encoding eLRR proteins."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In broader biomedical contexts, such as host responses to parasitic infection and in the genetics of refractive error, work on gene expression patterns supports a view in which proteins harboring LRR domains contribute to both immune and neural pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Finally, studies exploring cross‐kingdom regulation by microRNAs remind us of the diverse regulatory mechanisms that can influence genes involved in these networks"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", while high‐throughput approaches in mouse models further reinforce the versatility of genes implicated in neural and immune functions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings support the interpretation that LRIT2—by virtue of its inclusion in the eLRR protein family—is likely to function as a regulator of cellular interactions and signal transduction within the nervous system, with potential implications for neurodegeneration, neural development, and immune modulation.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Joseph H Lee, Rong Cheng, Sandra Barral, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of novel loci for Alzheimer disease and replication of CLU, PICALM, and BIN1 in Caribbean Hispanic individuals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Neurol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1001/archneurol.2010.292"}], "href": "https://doi.org/10.1001/archneurol.2010.292"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21059989"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21059989"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Christiane Reitz, Richard Mayeux "}, {"type": "b", "children": [{"type": "t", "text": "Genetics of Alzheimer's disease in Caribbean Hispanic and African American populations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Psychiatry (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopsych.2013.06.003"}], "href": "https://doi.org/10.1016/j.biopsych.2013.06.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23890735"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23890735"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jackie Dolan, Karen Walshe, Samantha Alsbury, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The extracellular leucine-rich repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2164-8-320"}], "href": "https://doi.org/10.1186/1471-2164-8-320"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17868438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17868438"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Evgenya Y Popova, Xuming Xu, Andrew T DeWan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stage and gene specific signatures defined by histones H3K4me2 and H3K27me3 accompany mammalian retina maturation in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0046867"}], "href": "https://doi.org/10.1371/journal.pone.0046867"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23056497"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23056497"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Bhagya K Wijayawardena, Dennis J Minchella, J Andrew DeWoody "}, {"type": "b", "children": [{"type": "t", "text": "The influence of trematode parasite burden on gene expression in a mammalian host."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12864-016-2950-5"}], "href": "https://doi.org/10.1186/s12864-016-2950-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27514777"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27514777"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Robert Wojciechowski, Ching-Yu Cheng "}, {"type": "b", "children": [{"type": "t", "text": "INVOLVEMENT OF MULTIPLE MOLECULAR PATHWAYS IN THE GENETICS OF OCULAR REFRACTION AND MYOPIA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Retina (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/IAE.0000000000001518"}], "href": "https://doi.org/10.1097/IAE.0000000000001518"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28406858"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28406858"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xuan Chen, Ren-Zhao Wu, Yong-Qiang Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Study on the inhibition of Mfn1 by plant-derived miR5338 mediating the treatment of BPH with rape bee pollen."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Complement Altern Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12906-018-2107-y"}], "href": "https://doi.org/10.1186/s12906-018-2107-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29382326"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29382326"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Chia-Yin Chiang, Yung-Hao Ching, Ting-Yan Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel eye genes systematically discovered through an integrated analysis of mouse transcriptomes and phenome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Comput Struct Biotechnol J (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.csbj.2019.12.009"}], "href": "https://doi.org/10.1016/j.csbj.2019.12.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31934309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31934309"}]}]}]}